Document Detail


A Massive Transfusion Protocol Incorporating a Higher FFP/RBC Ratio Is Associated With Decreased Use of Recombinant Activated Factor VII in Trauma Patients.
MedLine Citation:
PMID:  22431532     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
We implemented a protocol incorporating a higher fresh frozen plasma (FFP)/RBC ratio for the management of trauma patients requiring massive transfusion in 2007. This study aims to identify issues that affected the effective deployment of the massive transfusion protocol (MTP) and compare outcome variables with a historic cohort. Data from 49 trauma patients who received at least 10 units of packed RBCs within 24 hours were analyzed and compared with a historic massively transfused cohort who had received recombinant activated factor VII (rFVIIa). Of the patients, 28 received an FFP/RBC ratio of 1:1 to 1:2; 12 received a lower ratio of 1:2 to 1:4; 3 received more than 1:1 and 6 had less than 1:4. Compared with the historic cohort, the 1:1-1:2 group received significantly fewer blood components and did not require rescue rFVIIa. An MTP incorporating a higher FFP/RBC ratio of 1:1 to 1:2 is associated with decreased use of blood components and may obviate the need for rFVII.
Authors:
Josenia N M Tan; Peter A Burke; Suresh K Agarwal; Nelson Mantilla-Rey; Karen Quillen
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of clinical pathology     Volume:  137     ISSN:  1943-7722     ISO Abbreviation:  Am. J. Clin. Pathol.     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-03-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370470     Medline TA:  Am J Clin Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  566-71     Citation Subset:  AIM; IM    
Affiliation:
Dept of Pathology and Laboratory Medicine, Boston University Medical Center, One Boston Medical Center Place, Boston, MA 02118.
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