Document Detail

Massive OxyContin ingestion refractory to naloxone therapy.
MedLine Citation:
PMID:  12239500     Owner:  NLM     Status:  MEDLINE    
OxyContin (oxycodone hydrochloride controlled release) is a long-acting preparation of oxycodone that is used as an opioid analgesic to treat chronic pain conditions. We report a patient who ingested a massive quantity of OxyContin and had altered mental status, noncardiogenic pulmonary edema, and hypoventilation that proved refractory to naloxone administration. She required mechanical ventilation for 3 days before recovering completely. The severity and length of poisoning was likely related both to the quantity and formulation of the oxycodone ingested.
Aaron B Schneir; Tyler F Vadeboncoeur; Steven R Offerman; James D Barry; Binh T Ly; Saralyn R Williams; Richard F Clark
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Annals of emergency medicine     Volume:  40     ISSN:  0196-0644     ISO Abbreviation:  Ann Emerg Med     Publication Date:  2002 Oct 
Date Detail:
Created Date:  2002-09-19     Completed Date:  2002-10-16     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8002646     Medline TA:  Ann Emerg Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  425-8     Citation Subset:  AIM; IM    
Division of Medical Toxicology, Department of Emergency Medicine, University of California San Diego Medical Center, 92103-8925, USA.
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MeSH Terms
Middle Aged
Naloxone / therapeutic use*
Narcotic Antagonists / therapeutic use*
Narcotics / poisoning*
Oxycodone / antagonists & inhibitors,  poisoning*
Respiration, Artificial
Severity of Illness Index
Suicide, Attempted
Treatment Outcome
Reg. No./Substance:
0/Narcotic Antagonists; 0/Narcotics; 465-65-6/Naloxone; 76-42-6/Oxycodone

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