| Massive ascites associated with all-trans retinoic acid treatment in therapy-related acute promyelocytic leukemia. | |
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MedLine Citation:
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PMID: 20190483 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A 77-year-old man who developed pancytopenia was administered granulocyte colony-stimulating factor (G-CSF) by another doctor, and referred to us for the evaluation of pancytopenia. He had hepatocellular carcinoma and was treated with transcatheter arterial chemoembolization (TACE) containg epirubicin (total dose: 300 mg over the last two years). Bone marrow aspiration smear demonstrated hypercellular marrow with promyelocytes. Cytogenetic analysis demonstrated del(7), t(15;17)(q22;q12), and a fluorescence in-situ hybridization (FISH) study demonstrated chimeric fusion genes of PML-RAR-alpha. He was diagnosed with therapy-related acute promyelocytic leukemia (APL), and treated with all trans-retinoic acid (ATRA). He showed the progressive accumulation of ascites with liver damage, without pulmonary symptoms of ATRA differentiation syndrome. After 60 days of ATRA treatment, complete hematological and cytogenetic responses were achieved. However, the patient died of septic circulatory failure. |
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Authors:
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Munehiro Suzukawa; Tatsuki Nakazora; Yasufumi Kawasaki; Takayuki Tominaga; Kenji Shinohara |
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Publication Detail:
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Type: Case Reports; Journal Article Date: 2010-03-01 |
Journal Detail:
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Title: Internal medicine (Tokyo, Japan) Volume: 49 ISSN: 1349-7235 ISO Abbreviation: Intern. Med. Publication Date: 2010 |
Date Detail:
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Created Date: 2010-03-01 Completed Date: 2010-05-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9204241 Medline TA: Intern Med Country: Japan |
Other Details:
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Languages: eng Pagination: 457-60 Citation Subset: IM |
Affiliation:
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Division of Hematology, Department of Medicine, Yamaguchi Prefectural Medical Center, Hofu. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Antibiotics, Antineoplastic / administration & dosage Antineoplastic Agents / adverse effects, therapeutic use Ascites / chemically induced*, diagnosis* Carcinoma, Hepatocellular / therapy Chemoembolization, Therapeutic / adverse effects* Epirubicin / administration & dosage Humans Leukemia, Promyelocytic, Acute / drug therapy*, etiology* Liver Neoplasms / therapy Male Tretinoin / adverse effects*, therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Antibiotics, Antineoplastic; 0/Antineoplastic Agents; 302-79-4/Tretinoin; 56420-45-2/Epirubicin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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