Document Detail

Massage therapy by mothers enhances the adjustment of circadian rhythms to the nocturnal period in full-term infants.
MedLine Citation:
PMID:  12476070     Owner:  NLM     Status:  MEDLINE    
The objective of this study was to investigate the effect of massage therapy on phase adjustment of rest-activity and melatonin secretion rhythms to the nocturnal period in full-term infants. Rest-activity cycles of infants (measurement 1, n = 16) were measured by actigraphy before and after 14 days of massage therapy (starting at age 10 [+/-4] d) and subsequently at 6 and 8 weeks of age. 6-Sulphatoxymelatonin excretion was assessed in urine samples at 6, 8, and 12 weeks of age (measurement 2, n = 21). At 8 weeks the controls revealed one peak of activity at approximately 12 midnight (11 p.m.-3 a.m.) and another one at approximately 12 noon (11 a.m.-3 p.m.), whereas in the treated group, a major peak was early in the morning (3 a.m.-7 a.m.) and a secondary peak in the late afternoon (3 p.m.-7 p.m.). At 12 weeks, nocturnal 6-sulphatoxymelatonin excretions were significantly higher in the treated infants (1346.38 +/- 209.40 microg/night vs 823.25 +/- 121.25 microg/night, respectively; <.05). It is concluded that massage therapy by mothers in the perinatal period serves as a strong time cue, enhancing coordination of the developing circadian system with environmental cues.
Sari Goldstein Ferber; Moshe Laudon; Jacob Kuint; Aron Weller; Nava Zisapel
Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of developmental and behavioral pediatrics : JDBP     Volume:  23     ISSN:  0196-206X     ISO Abbreviation:  J Dev Behav Pediatr     Publication Date:  2002 Dec 
Date Detail:
Created Date:  2002-12-11     Completed Date:  2003-04-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8006933     Medline TA:  J Dev Behav Pediatr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  410-5     Citation Subset:  IM    
Department of Neonatology, Wolfson Medical Center, Sackler School of Medicine, Tel Aviv University, Tel Aviv.
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MeSH Terms
Adaptation, Physiological / physiology*
Circadian Rhythm / physiology*
Follow-Up Studies
Infant, Newborn
Melatonin / analogs & derivatives*,  urine
Mother-Child Relations*
Movement / physiology
Random Allocation
Sleep, REM / physiology
Reg. No./Substance:
2208-40-4/6-sulfatoxymelatonin; 73-31-4/Melatonin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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