| Mass protection program of perinatal hepatitis B virus infection in Japan and impact of an optional booster vaccination on its efficacy. | |
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MedLine Citation:
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PMID: 1785327 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We assessed the efficacy of a government-sponsored mass protection program in Osaka, Japan, for perinatal HBV infection in infants born to HBeAg positive HBV carrier mothers. We also evaluated the impact of optional follow-up procedures in such infants, including an evaluation of anti-HBs response and a booster dose of HBV vaccine for poor responders. The results demonstrated that this mass protection program protected 94.4% of the infants from perinatal HBV infection in the Osaka area. However, the proportion of infants with an unprotective level of anti-HBs was higher in the standard group than in the follow-up group both at 1.0 and 1.5 years of age, which was also the case for HBV events. Furthermore, the present study showed that a booster dose of vaccine in poor responders was very effective in promoting an anti-HBs response. In conclusion, we recommend that a follow-up blood test to confirm a response of anti-HBs to HBV vaccine should be performed at 4-8 weeks after the third injection of HBV vaccine in infants born to HBeAg positive HBV carrier mothers. We also recommend that a booster injection of HBV vaccine should be immediately given to poor responding infants who otherwise are at a considerable risk of developing HBV infection in late infancy. |
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Authors:
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H Tajiri; K Kozaiwa; T Harada; Y Ozaki; K Miki; K Shimizu; S Okada |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Acta paediatrica Japonica; Overseas edition Volume: 33 ISSN: 0374-5600 ISO Abbreviation: Acta Paediatr Jpn Publication Date: 1991 Jun |
Date Detail:
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Created Date: 1992-03-19 Completed Date: 1992-03-19 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370357 Medline TA: Acta Paediatr Jpn Country: JAPAN |
Other Details:
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Languages: eng Pagination: 323-6 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, Osaka University Hospital, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Female Fetal Diseases / prevention & control* Hepatitis B / immunology, prevention & control* Hepatitis B Surface Antigens / analysis, immunology Hepatitis B e Antigens / analysis, immunology Hepatitis B virus / immunology Humans Immunization, Secondary* Infant Infant, Newborn Japan Pregnancy Pregnancy Complications, Infectious / immunology* Prenatal Care / methods* Viral Hepatitis Vaccines / administration & dosage*, immunology |
| Chemical | |
Reg. No./Substance:
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0/Hepatitis B Surface Antigens; 0/Hepatitis B e Antigens; 0/Viral Hepatitis Vaccines |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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