Document Detail


Mass protection program of perinatal hepatitis B virus infection in Japan and impact of an optional booster vaccination on its efficacy.
MedLine Citation:
PMID:  1785327     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We assessed the efficacy of a government-sponsored mass protection program in Osaka, Japan, for perinatal HBV infection in infants born to HBeAg positive HBV carrier mothers. We also evaluated the impact of optional follow-up procedures in such infants, including an evaluation of anti-HBs response and a booster dose of HBV vaccine for poor responders. The results demonstrated that this mass protection program protected 94.4% of the infants from perinatal HBV infection in the Osaka area. However, the proportion of infants with an unprotective level of anti-HBs was higher in the standard group than in the follow-up group both at 1.0 and 1.5 years of age, which was also the case for HBV events. Furthermore, the present study showed that a booster dose of vaccine in poor responders was very effective in promoting an anti-HBs response. In conclusion, we recommend that a follow-up blood test to confirm a response of anti-HBs to HBV vaccine should be performed at 4-8 weeks after the third injection of HBV vaccine in infants born to HBeAg positive HBV carrier mothers. We also recommend that a booster injection of HBV vaccine should be immediately given to poor responding infants who otherwise are at a considerable risk of developing HBV infection in late infancy.
Authors:
H Tajiri; K Kozaiwa; T Harada; Y Ozaki; K Miki; K Shimizu; S Okada
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta paediatrica Japonica; Overseas edition     Volume:  33     ISSN:  0374-5600     ISO Abbreviation:  Acta Paediatr Jpn     Publication Date:  1991 Jun 
Date Detail:
Created Date:  1992-03-19     Completed Date:  1992-03-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370357     Medline TA:  Acta Paediatr Jpn     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  323-6     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, Osaka University Hospital, Japan.
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MeSH Terms
Descriptor/Qualifier:
Adult
Female
Fetal Diseases / prevention & control*
Hepatitis B / immunology,  prevention & control*
Hepatitis B Surface Antigens / analysis,  immunology
Hepatitis B e Antigens / analysis,  immunology
Hepatitis B virus / immunology
Humans
Immunization, Secondary*
Infant
Infant, Newborn
Japan
Pregnancy
Pregnancy Complications, Infectious / immunology*
Prenatal Care / methods*
Viral Hepatitis Vaccines / administration & dosage*,  immunology
Chemical
Reg. No./Substance:
0/Hepatitis B Surface Antigens; 0/Hepatitis B e Antigens; 0/Viral Hepatitis Vaccines

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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