Document Detail

Mass newborn screening in Singapore.
MedLine Citation:
PMID:  15906706     Owner:  NLM     Status:  MEDLINE    
Births in Singapore are almost exclusively in hospitals and this is conducive to mass newborn screening. Mass newborn screeningbegan in 1965 for G6PD deficiency and has led to successful eradication of the complicating kernicterus. Screening has also identified the distinct ethnic and sex linked variations in incidence. The predominant molecular abnormality is the Canton variant. Congenital hypothyroidism screening was started as a pilot project in 1981, then became institution-based in 1985 and nationwide in 1990. The screening is carried out on the cord blood and is now a primary TSH screen. Anincidence of about 1 in 3000 is being obtained and treatment has been started within 2 weeks of birth in almost all babies. A pilot Newborn Screening for hearing impairment started in 1999. Ituses the measurement of Transient Evoked Oto-Acoustic Emissions, is hospital based andcovers about 10% of the newborn population. The program has identified hearing impairment requiring intervention at a rate of about 1:1000 births. A program covering about 50% of the national births has been commissioned by the Ministry of Health to establish epidemiologic data and to document the outcome of early intervention. Mass newborn screening for inborn errors of metabolism is being considered.
Roy Joseph
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Southeast Asian journal of tropical medicine and public health     Volume:  34 Suppl 3     ISSN:  0125-1562     ISO Abbreviation:  Southeast Asian J. Trop. Med. Public Health     Publication Date:  2003  
Date Detail:
Created Date:  2005-05-23     Completed Date:  2005-07-01     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  0266303     Medline TA:  Southeast Asian J Trop Med Public Health     Country:  Thailand    
Other Details:
Languages:  eng     Pagination:  89-90     Citation Subset:  IM    
Department of Pediatrics, National University of Singapore, Singapore.
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MeSH Terms
Congenital Hypothyroidism
Health Policy
Hearing Tests
Hypothyroidism / diagnosis
Infant, Newborn
Neonatal Screening / methods*
Program Development
Program Evaluation*
Public Health Informatics

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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