Document Detail


Mass antimicrobial treatment in pregnancy. A randomized, placebo-controlled trial in a population with high rates of sexually transmitted diseases.
MedLine Citation:
PMID:  7776299     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Sexually transmitted diseases (STDs) are highly prevalent in pregnant women in many developing countries and have been associated with poor obstetric outcomes. Case detection and treatment of STDs in women is problematic and expensive, underscoring the need for other strategies. To explore the potential benefits of routine antimicrobial therapy on pregnancy outcome, we carried out a randomized, double-blind, clinical trial in one of the antenatal clinics in Nairobi, Kenya. Four hundred pregnant women between 28 and 32 weeks' gestation were given a single dose of 250 mg ceftriaxone intramuscularly or a placebo. There was a significant difference between ceftriaxone and placebo-treated women in infant birth weight (3,209 versus 3,056 g, P = .01). In addition, there was a trend toward lower rates of birth weight < 2,500 g (4.0% versus 9.2%, P = .08) and postpartum endometritis (3.8% versus 10.4%, P = .05) in the intervention than in the placebo group. Neisseria gonorrhoeae was isolated from the cervixes of postpartum women in 1.8% of the intervention group as compared to 4.2% of the control group. These data suggest a beneficial effect of antimicrobial prophylaxis on pregnancy outcome. Larger studies should be carried out to examine the public health impact of this intervention.
Authors:
M Temmerman; E Njagi; N Nagelkerke; J Ndinya-Achola; F A Plummer; A Meheus
Related Documents :
1858489 - Evaluation of symphysis-fundus measurements and weighing during pregnancy.
11169329 - Fetal weight estimation by three-dimensional ultrasound.
12237659 - The association between maternal factors and perinatal outcomes in triplet pregnancies.
15644509 - Changes in weight and composition in various tissues of pregnant gilts and their nutrit...
11641919 - Pregnancy weight gain and its correlation to birth weight.
2676639 - Fetal weight estimation in twin pregnancies.
18935999 - Successful treatment of twin-twin transfusion syndrome by occlusion of placental vessel...
2871239 - The fetal phonogram: a measure of fetal activity.
24597289 - Combined administration of gonadotropin-releasing hormone agonist with human chorionic ...
Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of reproductive medicine     Volume:  40     ISSN:  0024-7758     ISO Abbreviation:  J Reprod Med     Publication Date:  1995 Mar 
Date Detail:
Created Date:  1995-07-12     Completed Date:  1995-07-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0173343     Medline TA:  J Reprod Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  176-80     Citation Subset:  IM    
Affiliation:
Department of Medical Microbiology, University of Nairobi, Kenya.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Birth Weight
Ceftriaxone / therapeutic use*
Developing Countries
Double-Blind Method
Female
Humans
Kenya
Mass Screening
Pregnancy
Pregnancy Complications, Infectious / drug therapy*,  prevention & control
Pregnancy Outcome
Pregnancy Trimester, Third
Sexually Transmitted Diseases / drug therapy*,  prevention & control
Chemical
Reg. No./Substance:
73384-59-5/Ceftriaxone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Development of wound infection or separation after cesarean delivery. Prospective evaluation of 2,43...
Next Document:  Transvestibular retropubic bladder neck suspension. A pilot study.