| Mass Screening of Newborns for Congenital Hypothyroidism of Central Origin by Free Thyroxine Measurement of Blood Samples on Filter Paper. | |
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MedLine Citation:
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PMID: 22301913 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Objective: To evaluate the effectiveness of mass screening of newborns for congenital hypothyroidism of central origin (CH-C) by measurement of free T4 (FT4) and TSH.Design: Questionnaire-based survey of CH-C patients born between 1999 and 2008 in Kanagawa prefecture, Japan.Methods: TSH and FT4 levels in dried blood spots on filter paper were measured using ELISA kits, and CH-C was diagnosed at FT4 levels below a cutoff of 0.7 ng/dL (9.0 pmol/L). Survey results were collated with the database created by the screening organizer.Results: Twenty-four CH-C patients (18 males) were identified, 14 of whom had multiple pituitary hormone deficiencies (group M); 8, isolated CH-C (group I); and 2, undetermined pituitary involvement (group U). In groups M, I, and U, the number of patients with FT4 levels below the cutoff value at screening was 5 (36%), 7 (88%), and 1 (50%), respectively; other patients had been diagnosed clinically. Thus, 13 patients were true positives, while 9 were false negatives, yielding screening sensitivity of 59.1% and positive predictive value of 11.5%. The calculated sensitivity was 81.8% at a higher cutoff value of 0.9 ng/dL [11.6 pmol/L]. The overall incidence of CH-C was estimated at 1 in 30,833 live births, while that of congenital hypothyroidism of thyroidal origin (CH-T) is 1 in 3,472 live births in Kanagawa prefecture (CH-T/CH-C, 8.9).Conclusions: Newborn screening with combined FT4 and TSH measurements can identify a significant number of CH-C patients before manifestation of clinical symptoms, but a more appropriate FT4 cutoff value should be considered. |
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Authors:
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Masanori Adachi; Akiko Soneda; Yumi Asakura; Koji Muroya; Yuji Yamagami; Fumiki Hirahara |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-2-2 |
Journal Detail:
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Title: European journal of endocrinology / European Federation of Endocrine Societies Volume: - ISSN: 1479-683X ISO Abbreviation: - Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-2-3 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9423848 Medline TA: Eur J Endocrinol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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M Adachi, Department of Endocrinology and Metabolism, Kanagawa Children's Medical Center, Yokohama , Japan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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