| Maslinic acid derivatives induce significant apoptosis in b16f10 murine melanoma cells. | |
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MedLine Citation:
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PMID: 22019227 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Maslinic acid (2α,3β-dihydroxyolean-12-en-28-oic acid), a natural dihydroxylated pentacyclic triterpene acid isolated from olive-pressing residues, has been investigated together with some of its derivatives regarding the induction of apoptosis in B16F10 melanoma cells. Some of the compounds tested are described in this work, but others come from previous studies. Ten of these derivatives induce over 80% of apoptosis, clearly promoting cell death in B16F10 melanoma. By contrast, the induction cell death through necrosis was very slightly significant with these compounds. These results indicate that maslinic acid derivatives are promising chemopreventive and chemotherapeutic agents. |
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Authors:
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Andres Parra; Francisco Rivas; Samuel Martin-Fonseca; Andres Garcia-Granados; Antonio Martinez |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-10-12 |
Journal Detail:
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Title: European journal of medicinal chemistry Volume: - ISSN: 1768-3254 ISO Abbreviation: - Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-10-24 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0420510 Medline TA: Eur J Med Chem Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Elsevier Masson SAS. All rights reserved. |
Affiliation:
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Departamento de Quimica Organica, Facultad de Ciencias, Universidad de Granada, Fuentenueva, s/n, 18071-Granada, Spain. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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