Document Detail

Masked nocturnal hypertension--a novel marker of risk in type 2 diabetes.
MedLine Citation:
PMID:  19396423     Owner:  NLM     Status:  MEDLINE    
AIMS/HYPOTHESIS: This study was designed to evaluate the prevalence of masked nocturnal hypertension (MNHT) and its impact on arterial stiffness and central blood pressure in patients with type 2 diabetes. METHODS: Middle-aged patients (n = 414) with type 2 diabetes underwent clinic and ambulatory BP measurements and applanation tonometry. RESULTS: MNHT (clinic BP < 130/80 mmHg and night-time BP > or = 120/70 mmHg) was found in 7.2% of patients (n = 30). Compared with patients with both clinical and nocturnal normotension (n = 70), patients with MNHT had higher aortic pulse wave velocity (PWV) (10.2 +/- 1.8 m/s vs 9.4 +/- 1.7 m/s; p = 0.03) and higher central BP (117.6 +/- 13.9/74.0 +/- 9.1 mmHg vs 110.4 +/- 16.4/69.7 +/- 9.6 mmHg, p = 0.04). In patients with clinical normotension, night-time systolic BP correlated significantly with PWV. CONCLUSIONS/INTERPRETATION: Thirty per cent of patients with clinical normotension had nocturnal hypertension. This was accompanied by increased arterial stiffness and higher central BP. We conclude that in clinically normotensive patients with type 2 diabetes, ambulatory BP measurement may help clinicians to identify patients with increased cardiovascular risk.
M Wijkman; T Länne; J Engvall; T Lindström; C J Ostgren; F H Nystrom
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-04-25
Journal Detail:
Title:  Diabetologia     Volume:  52     ISSN:  1432-0428     ISO Abbreviation:  Diabetologia     Publication Date:  2009 Jul 
Date Detail:
Created Date:  2009-06-01     Completed Date:  2009-09-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0006777     Medline TA:  Diabetologia     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  1258-64     Citation Subset:  IM    
Department of Medical and Health Sciences, Faculty of Health Sciences, Linköping University, Linköping, Sweden.
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MeSH Terms
Antihypertensive Agents / therapeutic use
Aorta / physiopathology
Biological Markers
Blood Pressure
Blood Pressure Monitoring, Ambulatory
Circadian Rhythm*
Cohort Studies
Diabetes Mellitus, Type 2 / epidemiology*,  physiopathology*
Hypertension / drug therapy,  epidemiology*,  physiopathology*
Middle Aged
Predictive Value of Tests
Pulsatile Flow
Risk Factors
Reg. No./Substance:
0/Antihypertensive Agents; 0/Biological Markers

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