| Masked hypertension is prevalent in children with sickle cell disease: a Midwest Pediatric Nephrology Consortium study. | |
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MedLine Citation:
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PMID: 22886281 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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BACKGROUND: The prevalence of hypertension and abnormal blood pressure (BP) patterns on 24-h ambulatory BP monitoring (ABPM) remains unknown in children with sickle cell disease (SCD). METHODS: Thirty-eight asymptomatic children with sickle cell disease (SCD) (12 HbSS receiving routine care, 13 HbSC, and 13 HbSS receiving chronic transfusion therapy) underwent 24-h ABPM. Average clinic BP, demographic and biochemical characteristics were collected. RESULTS: Median age was 13 years (range 11-16), body mass index (BMI) 19.1 kg/m(2) (range 18.2-21.1), and 50% were male. Seventeen subjects (43.6%) had ambulatory hypertension, while 4 (10.3%) were hypertensive based on their clinic BP. Mean systolic blood pressure (SBP) and diastolic blood pressure (DBP) dip were 8.3 ± 5.9% and 14.7 ± 7.6% respectively. Twenty-three subjects (59%) had impaired SBP dipping, 7 (18%) had impaired DBP dipping, and 5 (13%) had reversed dipping. Clinic and ABP classification were modestly correlated (rho = 0.38, P = 0.02). CONCLUSION: Abnormalities in ABP measurements and patterns in children with SCD are prevalent and require more attention from heath care providers. ABPM is a valuable tool in identifying masked hypertension and abnormalities in circadian BP. |
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Authors:
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Ibrahim F Shatat; Sherron M Jakson; Amanda E Blue; Mary A Johnson; John K Orak; Ram Kalpatthi |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-8-11 |
Journal Detail:
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Title: Pediatric nephrology (Berlin, Germany) Volume: - ISSN: 1432-198X ISO Abbreviation: Pediatr. Nephrol. Publication Date: 2012 Aug |
Date Detail:
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Created Date: 2012-8-13 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8708728 Medline TA: Pediatr Nephrol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Division of Pediatric Nephrology and Hypertension, MUSC Children's Hospital, 96 Jonathan Lucas Street, CSB-428, Charleston, SC, 29425, USA, shatat@musc.edu. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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