| "Masculinizing" effect on respiratory morbidity in girls from unlike-sex preterm twins: a possible transchorionic paracrine effect. | |
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MedLine Citation:
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PMID: 17766488 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: Preterm male infants are at a disadvantage when compared with female infants regarding the incidence of respiratory and neurologic morbidity and mortality. At term, female infants from unlike-sex twin pairs have birth weights that are closer to their male co-twins than to girls from like-sex twin pairs. We hypothesized that if the male disadvantage is mediated via factors that affect fetal lung development, there may be a potential effect on the incidence of respiratory distress syndrome and its complications in female infants from unlike-sex pairs. PATIENTS AND METHODS: In this population-based study we used data from the Israel Neonatal Network, which included data from 8858 very low birth weight (500-1500 g) infants of 24 to 34 weeks' gestation. The incidence of morbidity and mortality was compared in male and female infants from singletons and like-sex and unlike-sex twin pairs. Multivariable analyses were used, accounting for relevant confounding variables. RESULTS: Male singletons and like-sex twins were at increased risk for mortality, respiratory distress syndrome, pneumothorax, bronchopulmonary dysplasia, periventricular-intraventricular hemorrhage, and periventricular leukomalacia. However, in unlike-sex twin pairs, no difference was seen in the incidence of respiratory morbidity between male and female twins. The male disadvantage was maintained for mortality and periventricular-intraventricular hemorrhage. CONCLUSIONS: These findings suggest that the difference in morbidity and mortality between male and female premature infants represents a male disadvantage as opposed to a female advantage and that this disadvantage may be transferred from boys to girls in unlike-sex twin pairs, perhaps via an intrauterine paracrine effect. |
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Authors:
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Eric S Shinwell; Brian Reichman; Liat Lerner-Geva; Valentina Boyko; Isaac Blickstein; |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Pediatrics Volume: 120 ISSN: 1098-4275 ISO Abbreviation: Pediatrics Publication Date: 2007 Sep |
Date Detail:
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Created Date: 2007-09-03 Completed Date: 2007-11-08 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0376422 Medline TA: Pediatrics Country: United States |
Other Details:
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Languages: eng Pagination: e447-53 Citation Subset: AIM; IM |
Affiliation:
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Department of Neonatology, Kaplan Medical Center, PO Box 1, Rehovot 76100, Israel. eric_s@clalit.org.il |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Bronchopulmonary Dysplasia
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epidemiology Cerebral Hemorrhage / epidemiology Databases as Topic Female Humans Infant Mortality Infant, Newborn Infant, Premature Infant, Very Low Birth Weight Leukomalacia, Periventricular / epidemiology Male Multivariate Analysis Paracrine Communication Pneumothorax / epidemiology Respiratory Distress Syndrome, Newborn / epidemiology* Risk Assessment Sex Factors Twins* |
| Comments/Corrections | |
Comment In:
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Pediatrics. 2007 Sep;120(3):638-9
[PMID:
17766536
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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