Document Detail


Of Marsupials and Men :"Backdoor" Dihydrotestosterone Synthesis In Male Sexual Differentiation.
MedLine Citation:
PMID:  23376007     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Following development of the fetal bipotential gonad into a testis, male genital differentiation requires testicular androgens. Fetal Leydig cells produce testosterone that is converted to dihydrotestosterone in genital skin, resulting in labio-scrotal fusion. An alternative 'backdoor' pathway of dihydrotestosterone synthesis that bypasses testosterone has been described in marsupials, but its relevance to human biology has been uncertain. The classic and backdoor pathways share many enzymes, but a 3α-reductase, AKR1C2, is unique to the backdoor pathway. Human AKR1C2 mutations cause disordered sexual differentiation, lending weight to the idea that both pathways are required for normal human male genital development. These observations indicate that fetal dihydrotestosterone acts both as a hormone and as a paracrine factor, substantially revising the classic paradigm for fetal male sexual development.
Authors:
Anna Biason-Lauber; Walter L Miller; Amit V Pandey; Christa E Flück
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-30
Journal Detail:
Title:  Molecular and cellular endocrinology     Volume:  -     ISSN:  1872-8057     ISO Abbreviation:  Mol. Cell. Endocrinol.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-2-4     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7500844     Medline TA:  Mol Cell Endocrinol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2013. Published by Elsevier Ireland Ltd.
Affiliation:
Department of Medicine, Division of Endocrinology , University of Fribourg , 1700 Fribourg, Switzerland (ABL);Department of Pediatrics, Division of Endocrinology, Diabetology and Metabolism, University Children's Hospital Bern, University of Bern, 3010 Bern, Switzerland (CEF, AVP);Dept. of Pediatrics, University of California, San Francisco;San Francisco, CA 94143-0978 (WLM). Electronic address: anna.lauber@unifr.ch.
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