Document Detail


Marsupial hypothalamo-neurohypophyseal hormones. The brush-tailed possum (Trichosurus vulpecula) active peptides.
MedLine Citation:
PMID:  7118406     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The hypothalamo-neurohypophyseal hormones of the brush-tailed possum (Trichosurus vulpecula) have been purified through molecular sieving and paper chromatoelectrophoresis. Two peptides have been isolated, one with pressor property, the other with uterotonic activity. The pressor hormone has been identified as arginine vasopressin by amino acid composition and amino acid sequence. The oxytocin-like hormone has been characterized as mesotocin by amino acid composition. The amounts per dried neuro-intermediate gland (1.0-1.5 mg) are approximately 12 and 5 nmol, respectively. Up to now, mesotocin has only been found in non-mammalian tetrapods, particularly in reptiles. Its preservation in Australian marsupials (Macropodidae and Phalangeridae), and the replacement of vasotocin by a vasopressin-like peptide, suggests that they are transition species between reptiles and Eutheria. However, the presence of mesotocin raises the question of its role in marsupial lactation.
Authors:
D Hurpet; M T Chauvet; J Chauvet; R Acher
Related Documents :
6250796 - Use of an octadecylsilica purification method minimizes proteolysis during isolation of...
2469426 - Efficacy of thyrotropin-releasing hormone in the treatment of cerebellar ataxia.
16844576 - Effects of growth hormone administration on skeletal muscle glutamine metabolism in sev...
2256436 - Characterization of the acidic forms of ovine pituitary luteinizing hormone.
21378556 - Vitamin supply in pregnancy for prevention of congenital birth defects.
10816116 - Lipid metabolism in peroxisomes: enzymology, functions and dysfunctions of the fatty ac...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of peptide and protein research     Volume:  19     ISSN:  0367-8377     ISO Abbreviation:  Int. J. Pept. Protein Res.     Publication Date:  1982 Apr 
Date Detail:
Created Date:  1982-12-03     Completed Date:  1982-12-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0330420     Medline TA:  Int J Pept Protein Res     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  366-71     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Amino Acids / analysis
Animals
Arginine Vasopressin / isolation & purification*
Biological Assay
Chromatography, Gel
Evolution
Hypothalamo-Hypophyseal System / analysis*
Opossums / physiology*
Oxytocin / analogs & derivatives*,  isolation & purification
Pituitary Gland / physiology
Rats
Chemical
Reg. No./Substance:
0/Amino Acids; 113-79-1/Arginine Vasopressin; 362-39-0/mesotocin; 50-56-6/Oxytocin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Peptide formation in the presence of metal ion protecting groups. II. Determination of the optical p...
Next Document:  Ribonuclease inhibitors from the livers of five mammalian species.