Document Detail

Marsupial hypothalamo-neurohypophyseal hormones. The brush-tailed possum (Trichosurus vulpecula) active peptides.
MedLine Citation:
PMID:  7118406     Owner:  NLM     Status:  MEDLINE    
The hypothalamo-neurohypophyseal hormones of the brush-tailed possum (Trichosurus vulpecula) have been purified through molecular sieving and paper chromatoelectrophoresis. Two peptides have been isolated, one with pressor property, the other with uterotonic activity. The pressor hormone has been identified as arginine vasopressin by amino acid composition and amino acid sequence. The oxytocin-like hormone has been characterized as mesotocin by amino acid composition. The amounts per dried neuro-intermediate gland (1.0-1.5 mg) are approximately 12 and 5 nmol, respectively. Up to now, mesotocin has only been found in non-mammalian tetrapods, particularly in reptiles. Its preservation in Australian marsupials (Macropodidae and Phalangeridae), and the replacement of vasotocin by a vasopressin-like peptide, suggests that they are transition species between reptiles and Eutheria. However, the presence of mesotocin raises the question of its role in marsupial lactation.
D Hurpet; M T Chauvet; J Chauvet; R Acher
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of peptide and protein research     Volume:  19     ISSN:  0367-8377     ISO Abbreviation:  Int. J. Pept. Protein Res.     Publication Date:  1982 Apr 
Date Detail:
Created Date:  1982-12-03     Completed Date:  1982-12-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0330420     Medline TA:  Int J Pept Protein Res     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  366-71     Citation Subset:  IM    
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MeSH Terms
Amino Acids / analysis
Arginine Vasopressin / isolation & purification*
Biological Assay
Chromatography, Gel
Hypothalamo-Hypophyseal System / analysis*
Opossums / physiology*
Oxytocin / analogs & derivatives*,  isolation & purification
Pituitary Gland / physiology
Reg. No./Substance:
0/Amino Acids; 113-79-1/Arginine Vasopressin; 362-39-0/mesotocin; 50-56-6/Oxytocin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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