Document Detail

Marrow graft studies in dogs: factors influencing resistance to engraftment and graft-versus-host disease.
MedLine Citation:
PMID:  6764839     Owner:  NLM     Status:  MEDLINE    
Our studies have provided further data to support the concept of resistance to engraftment in the dog. Resistance seems to be mediated by antigens coded for by loci different from but linked to DLA. Resistance can be abrogated by the addition of viable lymphoid cells to the marrow inoculum, by high-dose (fractionated) TBI of the recipient and by MTX given postgrafting. CyA has an adverse effect on engraftment probably by interfering with the graft-facilitating effect of donor lymphocytes. GVHD following allogeneic marrow transplantation appears to be mediated by DLA and non-DLA antigens. GVHD can be prevented or ameliorated in recipients of DLA identical littermate marrow by postgrafting CyA or MTX. With DLA nonidentical or unrelated grafts MTX or even more so a combination of MTX and CyA appear to be able to induce tolerance in some recipients.
H J Deeg; R Storb; E D Thomas
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Survey of immunologic research     Volume:  1     ISSN:  0252-9564     ISO Abbreviation:  Surv Immunol Res     Publication Date:  1982  
Date Detail:
Created Date:  1983-12-20     Completed Date:  1983-12-20     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8215669     Medline TA:  Surv Immunol Res     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  148-54     Citation Subset:  IM    
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MeSH Terms
Blood Transfusion
Bone Marrow Transplantation*
Cyclophosphamide / administration & dosage
Graft vs Host Disease / drug therapy,  genetics,  immunology*
Graft vs Host Reaction* / drug effects,  radiation effects
Histocompatibility Antigens / genetics,  immunology
Leukocyte Transfusion
Lymphocyte Depletion
Methotrexate / administration & dosage
Radiation Chimera
Grant Support
Reg. No./Substance:
0/Histocompatibility Antigens; 50-18-0/Cyclophosphamide; 59-05-2/Methotrexate

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