Document Detail


Marrow cell therapies for cardiovascular diseases.
MedLine Citation:
PMID:  18375038     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The nascent field of regenerative medicine has taken root in cardiovascular disease. Preclinical data demonstrating hemangioblast potential of marrow cells and cardioprotective effects of growth factors served as the basis for numerous early phase clinical trials. With the first wave of safety and efficacy trials complete, much is still unknown regarding optimal cell dose and type, timing of injection, route of administration, mechanisms of action, and achievable response measures. The next generation of studies will aim to answers these questions and make way for cellular therapies that result in effective cardiac repair.
Authors:
Christopher R Cogle; Gerard J Madlambayan; Grant Hubsher; Chris Beckman; Rachel Speisman; Roger Tran-Son-Tay; Carl J Pepine
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Publication Detail:
Type:  Journal Article; Review     Date:  2008-04-02
Journal Detail:
Title:  Experimental hematology     Volume:  36     ISSN:  0301-472X     ISO Abbreviation:  Exp. Hematol.     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-05-13     Completed Date:  2008-08-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0402313     Medline TA:  Exp Hematol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  687-94     Citation Subset:  IM    
Affiliation:
Department of Medicine, Division of Hematology/Oncology, Program in Stem Cell Biology and Regenerative Medicine, University of Florida College of Medicine, Gainesville, FL 32610-0278, USA. c@ufl.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Bone Marrow Cells
Bone Marrow Transplantation / methods*
Cardiovascular Diseases / surgery*
Clinical Trials as Topic
Cohort Studies
Disease Models, Animal
Humans
Myocardial Ischemia / surgery
Randomized Controlled Trials as Topic

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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