Document Detail


A Markov chain Monte Carlo strategy for sampling from the joint posterior distribution of pedigrees and population parameters under a Fisher-Wright model with partial selfing.
MedLine Citation:
PMID:  17448511     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A simple population genetic model is presented for a hermaphrodite annual species, allowing both selfing and outcrossing. Those male gametes (pollen) responsible for outcrossing are assumed to disperse much further than seeds. Under this model, the pedigree of a sample from a single locality is loop-free. A novel Markov chain Monte Carlo strategy is presented for sampling from the joint posterior distribution of the pedigree of such a sample and the parameters of the population genetic model (including the selfing rate) given the genotypes of the sampled individuals at unlinked marker loci. The computational costs of this Markov chain Monte Carlo strategy scale well with the number of individuals in the sample, and the number of marker loci, but increase exponentially with the age (time since colonisation from the source population) of the local population. Consequently, this strategy is particularly suited to situations where the sample has been collected from a population which is the result of a recent colonisation process.
Authors:
Ian J Wilson; Kevin J Dawson
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2007-03-12
Journal Detail:
Title:  Theoretical population biology     Volume:  72     ISSN:  0040-5809     ISO Abbreviation:  Theor Popul Biol     Publication Date:  2007 Nov 
Date Detail:
Created Date:  2007-10-08     Completed Date:  2008-01-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0256422     Medline TA:  Theor Popul Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  436-58     Citation Subset:  IM    
Affiliation:
Institute of Human Genetics, Newcastle University, International Centre for Life, Central Parkway, Newcastle upon Tyne, NE1 3BZ, UK. I.J.Wilson@ncl.ac.uk
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MeSH Terms
Descriptor/Qualifier:
Bayes Theorem
Gene Frequency
Genetics, Population*
Genotype
Humans
Markov Chains*
Models, Genetic
Models, Statistical
Monte Carlo Method*
Pedigree*
Probability
Stochastic Processes

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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