| Markers of uremia and pericardial effusion in peritoneal dialysis. | |
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MedLine Citation:
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PMID: 21853247 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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BACKGROUND: Inadequate dialysis causes accumulation of toxic residues that may lead to the development of dialysis-associated pericardial effusion, but several other factors could be associated with this abnormality. The purpose of this study was to evaluate clinical risk factors to asymptomatic pericardial effusion in peritoneal dialysis. METHODS: This cross-sectional study included 34 patients aged ≥18 years on peritoneal dialysis for at least 3 months, who showed no symptomatic pericardial effusion, hepatic cirrhosis, neoplasias, lupus or amputations, none in minoxidil use. Asymptomatic pericardial effusion was diagnosed by echocardiography. Risk factors were evaluated by logistic regression and Roc curve. Significance level was set at P < 0.05. RESULTS: Patient age was 51 ± 15.9 years. Of the 34 patients enrolled, 16 were men and 11 diabetic. Five of them presented pericardial effusion. Logistic regression identifies low hemoglobin level (RR 0.454 CI 95%: 0.225-0.913; P = 0.027), low phase angle (RR 0.236 CI 95%: 0.057-0.984; P = 0.048) and low Kt/V (RR 0.001 CI 95%: 0.0-0.492; P = 0.03) as risk factors to pericardial effusion. Roc curve showed that hemoglobin levels below 12.2 g/dL, Kt/V lower than 1.9 and phase angle lower than 4.5° were the best cutoffs to predict pericardial effusion. Four patients showed these three parameters in the unfavorable range, and all these four patients presented pericardial effusion. The other patient with pericardial effusion had two of these parameters reduced. CONCLUSIONS: These findings corroborate the hypothesis that uremia plays a significant role in the pathogenesis of dialysis-associated pericardial effusion. |
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Authors:
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Aline de Araujo Antunes; Jacqueline Costa Teixeira Caramori; Francieli Delatim Vannini; Silméia Garcia Zanati; Pasqual Barretti; Beatriz Bojikian Matsubara; Roberto Jorge da Silva Franco; Luis Cuadrado Martin |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-8-19 |
Journal Detail:
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Title: International urology and nephrology Volume: - ISSN: 1573-2584 ISO Abbreviation: - Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-8-19 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0262521 Medline TA: Int Urol Nephrol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Internal Medicine, Botucatu Medical School, São Paulo State University-UNESP, Botucatu, SP, 18618-970, Brazil, alineantunes@fmb.unesp.br. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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