| Markers of systemic inflammation in periodontal patients: chronic versus aggressive periodontitis. An explorative cross-sectional study. | |
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MedLine Citation:
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PMID: 20623039 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: The aim of this study was to evaluate differences in the inflammatory profile of young (<or=40 years) systemically healthy periodontal patients comparing chronic (CP) versus aggressive periodontitis (AP) in terms of cytokines, chemokines and C-reactive protein levels. METHODS: Systemically healthy subjects affected by severe CP or AP were enrolled in this study. Differential diagnosis was performed according to the criteria suggested by the American Academy of Periodontology. Blood samples for the evaluation of high sensitivity C-reactive protein levels, cytokine levels (IL-1beta, IL-1RA, IL-4, IL-6, IL-10, IL-12, interferon-gamma, interferon-gamma-inducible protein 10, tumour necrosis factor alpha) and chemokine levels (IL-8, vascular endothelial growth factor, monocyte chemoattractant protein 1, macrophage inflammatory protein 1alpha and macrophage inflammatory protein 1beta) were obtained from all patients. RESULTS: A total of 45 systemically healthy patients with severe periodontitis were consecutively selected, 21 with CP (mean age 36.8+/-3.5; mean clinical attachment level [CAL] 4.72+/-0.69) and 24 with AP (mean age 35.9+/-3.8; mean CAL 4.68+/-0.75). No statistically significant difference between the two groups was detected for periodontal variables and for all the investigated inflammatory markers. CONCLUSIONS: The inflammatory profile of severe periodontitis in young patients (<or=40 years) may be similar for chronic and aggressive types. Differential diagnosis between CP and AP may not be able to detect a different systemic inflammatory profile in young adults. |
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Authors:
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Francesco Cairo; Michele Nieri; Anna Maria Gori; Paolo Tonelli; Roberto Branchi; Sergio Castellani; Rosanna Abbate; Giovan Paolo Pini-Prato |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: European journal of oral implantology Volume: 3 ISSN: 1756-2406 ISO Abbreviation: Eur J Oral Implantol Publication Date: 2010 |
Date Detail:
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Created Date: 2010-07-12 Completed Date: 2010-09-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101473719 Medline TA: Eur J Oral Implantol Country: England |
Other Details:
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Languages: eng Pagination: 147-53 Citation Subset: D; IM |
Affiliation:
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Department of Periodontology, School of Dentistry, University of Florence, Florence, Italy. cairofrancesco@virgilio.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aggressive Periodontitis / blood* Analysis of Variance Biological Markers / blood C-Reactive Protein / analysis Chemokines / blood Chi-Square Distribution Chronic Periodontitis / blood* Cross-Sectional Studies Cytokines / blood Diagnosis, Differential Female Humans Inflammation / blood* Male |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Chemokines; 0/Cytokines; 9007-41-4/C-Reactive Protein |
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