Document Detail

Markers of stress and inflammation as potential mediators of the relationship between exercise and depressive symptoms: Findings from the TRAILS study.
MedLine Citation:
PMID:  25267470     Owner:  NLM     Status:  Publisher    
The hypothalamic-pituitary-adrenal axis, autonomic nervous system, and immune system have been proposed to underlie the antidepressant effect of exercise. Using a population sample of 715 adolescents, we examined whether pathways from exercise to affective and somatic symptoms of depression were mediated by these putative mechanisms. Exercise (hours/week) and depressive symptoms were assessed at age 13.5 (± 0.5) and 16.1 (± 0.6). Cortisol and heart rate responses to a standardized social stress test and C-reactive protein levels were measured at age 16. Exercise was prospectively and inversely related to affective (B = -0.16, 95% CI = -0.30 to -0.03) but not somatic symptoms (B = -0.04, 95% CI = -0.21 to 0.13). Heart rate during social stress partially mediated this relationship (B = -0.03, 95% CI = -0.07 to -0.01). No other mediating effects were found. Hence, the autonomic stress system may play a role in the relationship between exercise and depressive symptoms.
Sanne H Booij; Elisabeth H Bos; Peter de Jonge; Albertine J Oldehinkel
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-9-30
Journal Detail:
Title:  Psychophysiology     Volume:  -     ISSN:  1540-5958     ISO Abbreviation:  Psychophysiology     Publication Date:  2014 Sep 
Date Detail:
Created Date:  2014-9-30     Completed Date:  -     Revised Date:  2014-10-1    
Medline Journal Info:
Nlm Unique ID:  0142657     Medline TA:  Psychophysiology     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2014 Society for Psychophysiological Research.
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