Document Detail


Markers of sodium and volume homeostasis in pregnancy-induced hypertension.
MedLine Citation:
PMID:  1727815     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Normal pregnancy is associated with increased levels of digitalis-like factor (DLF) and erythrocyte sodium-lithium countertransport (RBC CTT), which return to normal levels postpartum. Patients with pregnancy-induced hypertension (PIH) have greater increases in both factors than women with normotensive pregnancies. This study was designed to determine if both abnormalities are observed concomitantly in PIH, if they correlate with blood pressure, if they correlate negatively with a hormonal index of volume status (PRA), and if they differ in women with and without proteinuria. Twenty-six normotensive women and 26 women with PIH were studied in the third trimester. Thirteen of these patients were also studied 6 months postpartum. Women with PIH, compared to those who were normotensive, had higher RBC CTT (0.49 +/- 0.04 vs. 0.36 +/- 0.03 mmol Li/L cells.h; P = 0.004) and DLF (0.30 +/- 0.3 vs. 0.20 +/- 0.03 microgram digoxin equiv./L; P = 0.01) and lower PRA [4.58 +/- 0.76 vs. 7.34 +/- 0.86 ng/mL.h (1.27 +/- 0.21 vs. 2.04 +/- 0.24 ng/L.s); P = 0.001]. All three parameters correlated significantly with diastolic blood pressures (RBC CTT and DLF positively (P less than or equal to 0.02) and PRA negatively (P = 0.03). Comparisons of DLF, RBC CTT, and PRA demonstrated a significant correlation of RBC CTT and DLF for normotensive pregnant women only (r = 0.38; P = 0.05). Patients with PIH were further analyzed according to whether proteinuria (24-h urinary protein, greater than 0.30 g; urine dipstick, greater than or equal to 2+) was present or absent. There was no significant difference in diastolic blood pressure or PRA between the hypertensive subpopulations, although there was a tendency for those without proteinuria to have lower PRAs [3.85 +/- 0.80 ng/mL.h (1.07 +/- 0.02 ng/L.s)] than those with proteinuria [5.31 +/- 1.30 ng/mL.h (1.48 +/- 0.36 ng/L.s)]. RBC CTT was significantly higher (P less than 0.05) in women with PIH without proteinuria, whereas serum DLF was significantly higher in women with PIH with proteinuria (P less than 0.05). In 13 women studied 6 months postpartum, there was a significant reduction in serum DLF, RBC CTT, and PRA for all women and in blood pressure for women who had had PIH (P less than 0.01). Thus, women with PIH, compared to normotensive pregnant women, had abnormalities in a variety of factors known to be volume sensitive or indicative of salt- and volume-sensitive forms of hypertension.(ABSTRACT TRUNCATED AT 400 WORDS)
Authors:
E W Seely; G H Williams; S W Graves
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of clinical endocrinology and metabolism     Volume:  74     ISSN:  0021-972X     ISO Abbreviation:  J. Clin. Endocrinol. Metab.     Publication Date:  1992 Jan 
Date Detail:
Created Date:  1992-01-30     Completed Date:  1992-01-30     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0375362     Medline TA:  J Clin Endocrinol Metab     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  150-6     Citation Subset:  AIM; IM    
Affiliation:
Endocrine-Hypertension Division, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115.
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MeSH Terms
Descriptor/Qualifier:
Adult
Antiporters*
Blood Pressure
Blood Proteins / metabolism
Blood Volume*
Cardenolides
Carrier Proteins / blood
Digoxin*
Erythrocytes / metabolism
Female
Homeostasis*
Humans
Hypertension / metabolism,  physiopathology*
Kidney / physiopathology
Postpartum Period
Pregnancy
Pregnancy Complications, Cardiovascular / metabolism,  physiopathology*
Renin / blood
Saponins*
Sodium / metabolism*
Grant Support
ID/Acronym/Agency:
5P50-HL-36568/HL/NHLBI NIH HHS; R01-HD-24499/HD/NICHD NIH HHS; RR-02635/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Antiporters; 0/Blood Proteins; 0/Cardenolides; 0/Carrier Proteins; 0/Saponins; 0/digoxin-like factors; 0/sodium-lithium countertransporter; 20830-75-5/Digoxin; 7440-23-5/Sodium; EC 3.4.23.15/Renin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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