Document Detail

Markers of redox imbalance in the blood of hypertensive patients of a community in Northeastern Brazil.
MedLine Citation:
PMID:  22002029     Owner:  NLM     Status:  Publisher    
BACKGROUND: Recent studies describe the participation of reactive oxygen and nitrogen species in hypertension. OBJECTIVE: To identify the redox imbalance in the blood of hypertensive. METHODS: Superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione (GSH), vitamin C, transferrin, ceruloplasmin, malondialdehyde (MDA) and carbonyl group were quantified in the blood of 20 hypertensives and 21 controls. The individuals had a Body Mass Index of > 18.5 and < 30 kg/m², glycemia < 100 mg/dL, serum cholesterol < 200 mg/dL, and were nonsmokers, non-pregnant and non-lactating women, non-users of alopurinol and probucol, with hypertensives on antihypertensive medication. All individuals underwent a preparatory period of 4 weeks without alcohol, vitamin supplements, dexamethasone and paracetamol. RESULTS: Reduced levels of CAT (p 0.013), GSH (p 0.003) and MDA (p 0.014), and high levels of GPx (p 0.001) and ceruloplasmin (p 0.015) were obtained in the hypertensive group compared with controls. A positive correlation between systolic pressure and MDA in hypertensive and diastolic pressure and CAT in controls was obtained. CONCLUSION: The data obtained suggest that the hypertensives were in redox imbalance, despite the possibly attenuating effect of their antihypertensive medication.
Sandra Mary Lima Vasconcelos; Marília Oliveira Fonseca Goulart; Maria Alayde Mendonça da Silva; Vanusa Manfredini; Mara da Silveira Benfato; Luiza Antas Rabelo; Gilberto Fontes
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Publication Detail:
Journal Detail:
Title:  Arquivos brasileiros de cardiologia     Volume:  97     ISSN:  1678-4170     ISO Abbreviation:  -     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-10-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0421031     Medline TA:  Arq Bras Cardiol     Country:  -    
Other Details:
Languages:  SPA; ENG; POR     Pagination:  141-147     Citation Subset:  -    
Universidade Federal de Alagoas, Maceió, AL, Brasil.
Vernacular Title:
Marcadores de desequilíbrio redox em sangue de pacientes hipertensos de uma comunidade no Nordeste do Brasil.
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