Document Detail


Markers of redox imbalance in the blood of hypertensive patients of a community in Northeastern Brazil.
MedLine Citation:
PMID:  22002029     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND: Recent studies describe the participation of reactive oxygen and nitrogen species in hypertension. OBJECTIVE: To identify the redox imbalance in the blood of hypertensive. METHODS: Superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione (GSH), vitamin C, transferrin, ceruloplasmin, malondialdehyde (MDA) and carbonyl group were quantified in the blood of 20 hypertensives and 21 controls. The individuals had a Body Mass Index of > 18.5 and < 30 kg/m², glycemia < 100 mg/dL, serum cholesterol < 200 mg/dL, and were nonsmokers, non-pregnant and non-lactating women, non-users of alopurinol and probucol, with hypertensives on antihypertensive medication. All individuals underwent a preparatory period of 4 weeks without alcohol, vitamin supplements, dexamethasone and paracetamol. RESULTS: Reduced levels of CAT (p 0.013), GSH (p 0.003) and MDA (p 0.014), and high levels of GPx (p 0.001) and ceruloplasmin (p 0.015) were obtained in the hypertensive group compared with controls. A positive correlation between systolic pressure and MDA in hypertensive and diastolic pressure and CAT in controls was obtained. CONCLUSION: The data obtained suggest that the hypertensives were in redox imbalance, despite the possibly attenuating effect of their antihypertensive medication.
Authors:
Sandra Mary Lima Vasconcelos; Marília Oliveira Fonseca Goulart; Maria Alayde Mendonça da Silva; Vanusa Manfredini; Mara da Silveira Benfato; Luiza Antas Rabelo; Gilberto Fontes
Related Documents :
16897419 - Unrestrained acoustic plethysmograph for measuring tidal volume in mice.
2158209 - Alpha-adrenergic regulation of splanchnic volume and cardiac output in the dog.
21661019 - Bladder compliance what does it represent: can we measure it, and is it clinically rele...
10656349 - Refinements of environmental assessment during an outbreak investigation of invasive as...
12771609 - Usefulness of left ventricular stroke volume variation to assess fluid responsiveness i...
7569659 - Manometric rhinometry: a new method of measuring nasal volume.
2969039 - Hypertensive complications and home blood pressure: comparison with blood pressure meas...
17376689 - Gait termination in lower limb amputees.
750669 - Sodium metabolism in essential hypertension. natriuretic response to acute hypertonic s...
Publication Detail:
Type:  JOURNAL ARTICLE    
Journal Detail:
Title:  Arquivos brasileiros de cardiologia     Volume:  97     ISSN:  1678-4170     ISO Abbreviation:  -     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-10-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0421031     Medline TA:  Arq Bras Cardiol     Country:  -    
Other Details:
Languages:  SPA; ENG; POR     Pagination:  141-147     Citation Subset:  -    
Affiliation:
Universidade Federal de Alagoas, Maceió, AL, Brasil.
Vernacular Title:
Marcadores de desequilíbrio redox em sangue de pacientes hipertensos de uma comunidade no Nordeste do Brasil.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Anti-tumor Function of Double-promoter Regulated Adenovirus Carrying SEA Gene, in the Treatment of B...
Next Document:  Atypical truncus arteriosus operated at 28 years of age: importance of differential diagnosis.