Document Detail

Markers of oxidative stress and systemic vasoconstriction in pregnant women drinking > or =48 g of alcohol per day.
MedLine Citation:
PMID:  18715278     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The precise pathway by which alcohol causes the characteristic features of fetal alcohol spectrum disorders is unknown. Proposed mechanisms for fetal injury from maternal alcohol use include cellular damage from oxidative stress and impaired fetal oxygenation related to maternal systemic vasoconstriction. Our objective was to compare the levels of urinary markers of oxidative stress and systemic vasoconstriction between women consuming large amounts of alcohol during pregnancy and women who did not drink alcohol during pregnancy.
METHODS: Pregnant women consuming > or =48 g alcohol per day (n = 29) on average and pregnant women who abstained from alcohol use (n = 39) were identified using detailed interviews and home visits. Random maternal urine specimens were collected. Urinary levels of the oxidative stress marker, 8-isoprostane F2alpha, and of the vasoactive prostaglandin metabolites, 2,3-dinor-6-keto-prostaglandin F1alpha (a vasodilator) and 11-dehydro-thromboxane B2 (a vasoconstrictor), were measured using mass spectrometric methods. All analyte levels were corrected for urinary creatinine.
RESULTS: In crude analyses, there was no significant difference in 8-isoprostane F2alpha between pregnant drinkers and nondrinkers (2.16 vs. 2.08 ng/mg creatinine, respectively, p = 0.87). There were no significant differences between the drinking and nondrinking groups in levels of 2,3-dinor-6-keto-prostaglandin F1alpha (1.03 vs. 1.17 ng/mg creatinine, respectively, p = 0.50), 11-dehydro-thromboxane B2 (0.72 vs. 0.59 ng/mg creatinine, respectively, p = 0.21), or the ratio of vasodilatory metabolite to vasoconstrictive metabolite (1.73 vs. 2.72, respectively, p = 0.14). Adjusting for maternal age, marital status, smoking, and gestational age at sampling did not substantially alter the results.
CONCLUSION: Our results show no difference in levels of urinary eicosanoid markers of oxidative stress and systemic vasoconstriction between pregnant women who drink heavily and pregnant women who abstain. These findings speak against a role for maternal oxidative stress or systemic vasoconstriction in the pathogenesis of alcohol damage to the fetus.
Caroline Signore; Sofía Aros; Jason D Morrow; James Troendle; Mary R Conley; Elizabeth Y Flanigan; Fernando Cassorla; James L Mills
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural     Date:  2008-08-18
Journal Detail:
Title:  Alcoholism, clinical and experimental research     Volume:  32     ISSN:  1530-0277     ISO Abbreviation:  Alcohol. Clin. Exp. Res.     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2008-11-26     Completed Date:  2009-02-09     Revised Date:  2013-06-05    
Medline Journal Info:
Nlm Unique ID:  7707242     Medline TA:  Alcohol Clin Exp Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  1893-8     Citation Subset:  IM    
Epidemiology Branch, Division of Epidemiology, Statistics, and Prevention Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA.
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MeSH Terms
6-Ketoprostaglandin F1 alpha / analogs & derivatives,  urine
Alcohol Drinking / adverse effects,  physiopathology*
Case-Control Studies
Central Nervous System Depressants / adverse effects
Cohort Studies
Dinoprost / analogs & derivatives,  urine
Eicosanoids / urine*
Ethanol / adverse effects
Fetal Alcohol Syndrome / etiology*,  physiopathology
Follow-Up Studies
Isoprostanes / urine*
Oxidative Stress / physiology*
Thromboxane B2 / analogs & derivatives,  urine
Vasoconstriction / physiology*
Young Adult
Grant Support
Reg. No./Substance:
0/Central Nervous System Depressants; 0/Eicosanoids; 0/Isoprostanes; 27415-26-5/8-epi-prostaglandin F2alpha; 54397-85-2/Thromboxane B2; 551-11-1/Dinoprost; 58962-34-8/6-Ketoprostaglandin F1 alpha; 64-17-5/Ethanol; 64700-71-6/2,3-dinor-6-ketoprostaglandin F1alpha; 67910-12-7/11-dehydro-thromboxane B2

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