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Markers of microbial translocation and risk of AIDS-related lymphoma.
MedLine Citation:
PMID:  23169327     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Depletion of gut-associated lymphocytes by HIV infection facilitates microbial translocation, which may contribute to non-Hodgkin lymphoma (NHL) risk via chronic immune activation and B-cell hyperstimulation. We therefore examined associations of four microbial translocation markers with subsequent NHL risk in a case-control study nested within 4 prospective cohort studies of HIV-infected individuals. Pre-diagnostic blood specimens for 56 NHL cases and 190 controls matched on age, sex, race, specimen type, cohort, and CD4+ T-cell count were tested for the endotoxin lipopolysaccharide (LPS), anti-endotoxin core antibody (EndoCab), LPS binding protein (LBP), and soluble CD14 (sCD14). Elevated levels of sCD14 were associated with significantly increased NHL risk (OR: 2.72 [95% CI:1.29, 5.76]). In sub-group analyses, elevated LPS levels were also associated with significantly increased NHL risk (OR: 3.24 [95% CI:1.10, 9.53]). EndoCab and LBP levels were not associated with NHL risk. The association of sCD14 and LPS with NHL risk supports an etiologic role for gut microbial translocation in lymphomagenesis among HIV-infected individuals. Additional studies with larger sample sizes are needed to confirm these observations.
Authors:
Morgan A Marks; Charles S Rabkin; Eric A Engels; Evan Busch; William Kopp; Helen Rager; James J Goedert; Anil K Chaturvedi
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-19
Journal Detail:
Title:  AIDS (London, England)     Volume:  -     ISSN:  1473-5571     ISO Abbreviation:  AIDS     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8710219     Medline TA:  AIDS     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
aInfections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD bDepartment of Epidemiology, University of North Carolina, Chapel Hill, NC cClinical Support Laboratory, SAIC-Frederick, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD.
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