Document Detail

Markers of inflammation, vitamin E and peripheral nervous system function: the InCHIANTI study.
MedLine Citation:
PMID:  16112778     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Aging of the peripheral nervous system is associated with several morphologic and functional changes, including a decrease of the nerve conduction velocity. There is evidence that these changes contribute to age-related-decline in muscle strength, sensory discrimination, and autonomic responses. The aim of this study was to characterize the decline in nerve conduction velocity in the peripheral nervous system over the aging process and to identify factors that, independent of age, affect nerve conduction velocity.
METHODS: We measured motor nerve conduction velocity of the right superficial peroneal nerve using a standard neurophysiologic technique in a population-based sample of subjects aged between 20 and 103 years old enrolled in the InCHIANTI study.
RESULTS: Average conduction velocities in the peripheral nerve decreased linearly with age in both sexes. We found that diabetes, cognitive impairment, uric acid, sIL-6R and alpha-tocopherol were significant predictors of nerve conduction velocity independently of the potential confounding effect of age, sex, sex x age interaction term, height, lymphocytes, neutrophils number, alpha1 and alpha2-globulin serum protein.
CONCLUSIONS: Our findings are consistent with the hypothesis that inflammation and inadequate antioxidant defenses are associated with accelerated decline of nerve conduction velocity over the aging process.
Angelo Di Iorio; Antonio Cherubini; Stefano Volpato; Eleonora Sparvieri; Fulvio Lauretani; Claudio Franceschi; Umberto Senin; Giuseppe Abate; Roberto Paganelli; Antonio Martin; Cristina Andres-Lacueva; Luigi Ferrucci
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2005-08-22
Journal Detail:
Title:  Neurobiology of aging     Volume:  27     ISSN:  1558-1497     ISO Abbreviation:  Neurobiol. Aging     Publication Date:  2006 Sep 
Date Detail:
Created Date:  2006-07-24     Completed Date:  2006-08-28     Revised Date:  2012-03-07    
Medline Journal Info:
Nlm Unique ID:  8100437     Medline TA:  Neurobiol Aging     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1280-8     Citation Subset:  IM    
Laboratory of Clinical Epidemiology, Department of Medicine and Sciences of Aging, University G. D'Annunzio, Via dei Vestini 5, 66013 Chieti Scalo, Italy.
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MeSH Terms
Age Factors
Aged, 80 and over
Aging / physiology*
Biological Markers
Chromatography, High Pressure Liquid / methods
Cluster Analysis
Cytokines / blood
Electric Stimulation / methods
Electromyography / methods
Inflammation / diagnosis,  metabolism*
Linear Models
Middle Aged
Neural Conduction / physiology*
Peripheral Nervous System / physiology*
Reaction Time / physiology
Sex Factors
Vitamin E / metabolism*
Grant Support
Reg. No./Substance:
0/Biological Markers; 0/Cytokines; 1406-18-4/Vitamin E

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