Document Detail


Markers of inflammation and oxidative stress in peritoneal dialysis: a comparison between high and low peritoneal transporters.
MedLine Citation:
PMID:  20349414     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
INTRODUCTION: High transport status is reported to be associated with increased mortality in peritoneal dialysis (PD). It has been hypothesized that this might be a result of a state of chronic inflammation and increased oxidative stress. We performed this pilot study to explore this hypothesis. METHODS: Based on the standard peritoneal equilibration test, PD patients were divided in two transporter groups: LOW (Low + Low average) and HIGH (High + High Average). Markers of inflammation and oxidative stress were compared between the two groups, including C-reactive protein (CRP), plasma apoptogenic potential, monocyte HLA DR expression, Advanced Oxidative Protein Products (AOPP) and reactive carbonyl residues (RCO). RESULTS: Of 42 patients (34 male/8 female) studied, 8 patients were LOW and 34 were HIGH transporters. Median values of CRP (1.39 vs. 0.62 mg/L), plasma apoptogenic potential (15 vs. 14.5%), AOPP (118.36 vs. 113.86 micromol/L) and RCO (1.72 vs. 1.13 nmol/mg protein) were similar among LOW and HIGH transporters. However HIGH transporters had significantly lower monocyte HLA DR expression (mean fluorescent intensity (MFI) -197.89 vs. 124.98 units, p=0.02) compared with LOW transporters. CONCLUSIONS: Stable chronic PD patients with high peritoneal transport status have reduced monocyte HLA-DR expression, a biomarker of increased risk for infections. This could potentially contribute to a higher risk of mortality in this group.
Authors:
Dinna N Cruz; Sachin S Soni; Natalia Polanco; Ilona Bobek; Valentina Corradi; Massimo de Cal; Claudio Ronco
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of nephrology     Volume:  23     ISSN:  1121-8428     ISO Abbreviation:  J. Nephrol.     Publication Date:    2010 Jul-Aug
Date Detail:
Created Date:  2010-07-12     Completed Date:  2010-09-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9012268     Medline TA:  J Nephrol     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  453-8     Citation Subset:  IM    
Affiliation:
Department of Nephrology, San Bortolo Hospital, Vicenza, Italy.
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MeSH Terms
Descriptor/Qualifier:
Aged
Biological Markers
Biological Transport
C-Reactive Protein / analysis
Cross-Sectional Studies
Female
HLA-DR Antigens / blood
Humans
Inflammation / blood*
Male
Middle Aged
Oxidative Stress*
Peritoneal Dialysis*
Peritoneum / metabolism*
U937 Cells
Chemical
Reg. No./Substance:
0/Biological Markers; 0/HLA-DR Antigens; 9007-41-4/C-Reactive Protein

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