| Markers of inflammation and oxidative stress in peritoneal dialysis: a comparison between high and low peritoneal transporters. | |
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MedLine Citation:
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PMID: 20349414 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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INTRODUCTION: High transport status is reported to be associated with increased mortality in peritoneal dialysis (PD). It has been hypothesized that this might be a result of a state of chronic inflammation and increased oxidative stress. We performed this pilot study to explore this hypothesis. METHODS: Based on the standard peritoneal equilibration test, PD patients were divided in two transporter groups: LOW (Low + Low average) and HIGH (High + High Average). Markers of inflammation and oxidative stress were compared between the two groups, including C-reactive protein (CRP), plasma apoptogenic potential, monocyte HLA DR expression, Advanced Oxidative Protein Products (AOPP) and reactive carbonyl residues (RCO). RESULTS: Of 42 patients (34 male/8 female) studied, 8 patients were LOW and 34 were HIGH transporters. Median values of CRP (1.39 vs. 0.62 mg/L), plasma apoptogenic potential (15 vs. 14.5%), AOPP (118.36 vs. 113.86 micromol/L) and RCO (1.72 vs. 1.13 nmol/mg protein) were similar among LOW and HIGH transporters. However HIGH transporters had significantly lower monocyte HLA DR expression (mean fluorescent intensity (MFI) -197.89 vs. 124.98 units, p=0.02) compared with LOW transporters. CONCLUSIONS: Stable chronic PD patients with high peritoneal transport status have reduced monocyte HLA-DR expression, a biomarker of increased risk for infections. This could potentially contribute to a higher risk of mortality in this group. |
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Authors:
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Dinna N Cruz; Sachin S Soni; Natalia Polanco; Ilona Bobek; Valentina Corradi; Massimo de Cal; Claudio Ronco |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Journal of nephrology Volume: 23 ISSN: 1121-8428 ISO Abbreviation: J. Nephrol. Publication Date: 2010 Jul-Aug |
Date Detail:
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Created Date: 2010-07-12 Completed Date: 2010-09-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9012268 Medline TA: J Nephrol Country: Italy |
Other Details:
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Languages: eng Pagination: 453-8 Citation Subset: IM |
Affiliation:
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Department of Nephrology, San Bortolo Hospital, Vicenza, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Biological Markers Biological Transport C-Reactive Protein / analysis Cross-Sectional Studies Female HLA-DR Antigens / blood Humans Inflammation / blood* Male Middle Aged Oxidative Stress* Peritoneal Dialysis* Peritoneum / metabolism* U937 Cells |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/HLA-DR Antigens; 9007-41-4/C-Reactive Protein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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