Document Detail

Markers of inflammation are inversely associated with VO2 max in asymptomatic men.
MedLine Citation:
PMID:  17170204     Owner:  NLM     Status:  MEDLINE    
We investigated whether markers of inflammation, including a cytokine (IL-6), acute-phase reactants [C-reactive protein (CRP) and fibrinogen], and white blood cell (WBC) count are associated with maximal O(2) consumption (Vo(2 max)) in men without coronary heart disease (CHD). In asymptomatic men (n = 172, 51 +/- 9.3 yr old), Vo(2 max) was measured during a symptom-limited graded treadmill exercise test. Physical activity level was assessed by a standardized questionnaire. IL-6 and CRP were measured by immunoassays, fibrinogen by the Clauss method, and WBC count with a Coulter counter. IL-6 and CRP were logarithmically transformed to reduce skewness. Multivariable regression was used to assess whether markers of inflammation were associated with Vo(2 max) after adjustment for age, body mass index, CHD risk factors, and lifestyle variables (physical activity level, percent body fat, and alcohol intake). Vo(2 max) was 34.5 (SD 6.1). Log IL-6 (r = -0.38, P < 0.001), log CRP (r = -0.40, P < 0.001), fibrinogen (r = -0.42, P < 0.001), and WBC count (r = -0.22, P = 0.004) were each correlated with Vo(2 max). In separate multivariable linear regression models that adjusted for age, body mass index, CHD risk factors, and lifestyle variables, log IL-6 [beta-coeff = -1.66 +/- 0.63 (SE), P = 0.010], log CRP [beta-coeff = -0.99 +/- 0.33 (SE), P = 0.003], fibrinogen [beta-coeff = -1.51 +/- 0.44 (SE), P = 0.001], and WBC count [beta-coeff = -0.52 +/- 0.30 (SE), P = 0.088] were each inversely associated with Vo(2 max). In conclusion, higher circulating levels of IL-6, CRP, and fibrinogen are independently associated with lower Vo(2 max) in asymptomatic men.
Iftikhar J Kullo; Mahyar Khaleghi; Donald D Hensrud
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2006-12-14
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  102     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-04-05     Completed Date:  2007-05-22     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1374-9     Citation Subset:  IM    
Division of Cardiovascular Diseases, Department of Internal Medicine, Mayo College of Medicine, Rochester, Minnesota, USA.
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MeSH Terms
Acute-Phase Proteins / analysis*
Aged, 80 and over
Biological Markers / blood
Coronary Artery Disease / physiopathology
Fibrinogen / analysis*
Inflammation / pathology,  physiopathology*
Interleukin-6 / blood*
Leukocyte Count
Middle Aged
Oxygen / metabolism*
Oxygen Consumption*
Physical Endurance*
Physical Fitness
Statistics as Topic
Grant Support
Reg. No./Substance:
0/Acute-Phase Proteins; 0/Biological Markers; 0/Interleukin-6; 7782-44-7/Oxygen; 9001-32-5/Fibrinogen

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