Document Detail


Markers of inflammation and CD8 T-cell activation, but not monocyte activation, are associated with subclinical carotid artery disease in HIV-infected individuals.
MedLine Citation:
PMID:  23332012     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: The aim of the study was to explore the relationships between lymphocyte and monocyte activation, inflammation, and subclinical vascular disease among HIV-1-infected patients on antiretroviral therapy (ART).
METHODS: Baseline mean common carotid artery (CCA) intima-media thickness (IMT) and carotid plaque (IMT > 1.5 cm) were evaluated in the first 60 subjects enrolled in the Stopping Atherosclerosis and Treating Unhealthy Bone with Rosuvastatin in HIV (SATURN-HIV) trial. All subjects were adults on stable ART with evidence of heightened T-cell activation (CD8(+)CD38(+)HLA-DR(+) ≥ 19%) or increased inflammation (high-sensitivity C-reactive protein ≥ 2 mg/L). All had fasting low-density lipoprotein (LDL) cholesterol ≤ 130 mg/dL.
RESULTS: Seventy-eight per cent of patients were men and 65% were African-American. Median (interquartile range) age and CD4 count were 47 (43, 52) years and 648 (511, 857) cells/μL, respectively. All had HIV-1 RNA < 400 HIV-1 RNA copies/mL. Mean CCA-IMT was correlated with log-transformed CD8(+)CD38(+)HLA-DR(+) percentage (r = 0.326; P = 0.043), and concentrations of interleukin-6 (r = 0.283; P = 0.028), soluble vascular cell adhesion molecule (sVCAM; r = 0.434; P = 0.004), tumour necrosis factor-α receptor-I (TNFR-I; r = 0.591; P < 0.0001) and fibrinogen (r = 0.257; P = 0.047). After adjustment for traditional cardiovascular disease (CVD) risk factors, the association with TNFR-I (P = 0.007) and fibrinogen (P = 0.033) remained significant. Subjects with plaque (n = 22; 37%) were older [mean (standard deviation) 51 (7.7) vs. 43 (9.4) years, respectively; P = 0.002], and had a higher CD8(+)CD38(+)HLA-DR(+) percentage [median (interquartile range) 31% (24, 41%) vs. 23% (20, 29%), respectively; P = 0.046] and a higher sVCAM concentration [mean (standard deviation) 737 (159) vs. 592 (160) ng/mL, respectively; P = 0.008] compared with those without plaque. Pro-inflammatory monocyte subsets and serum markers of monocyte activation (soluble CD163 and soluble CD14) were not associated with CCA-IMT or plaque.
CONCLUSIONS: Participants in SATURN-HIV have a high level of inflammation and immune activation that is associated with subclinical vascular disease despite low serum LDL cholesterol.
Authors:
C T Longenecker; N T Funderburg; Y Jiang; S Debanne; N Storer; D E Labbato; M M Lederman; G A McComsey
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural     Date:  2013-01-18
Journal Detail:
Title:  HIV medicine     Volume:  14     ISSN:  1468-1293     ISO Abbreviation:  HIV Med.     Publication Date:  2013 Jul 
Date Detail:
Created Date:  2013-06-06     Completed Date:  2013-12-09     Revised Date:  2014-07-02    
Medline Journal Info:
Nlm Unique ID:  100897392     Medline TA:  HIV Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  385-90     Citation Subset:  IM    
Copyright Information:
© 2013 British HIV Association.
Data Bank Information
Bank Name/Acc. No.:
ClinicalTrials.gov/NCT01218802
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MeSH Terms
Descriptor/Qualifier:
Adult
Anti-Retroviral Agents / therapeutic use
CD8-Positive T-Lymphocytes / immunology*
Carotid Artery Diseases / immunology*,  pathology
Cholesterol, LDL / blood
Cross-Sectional Studies
Female
HIV Infections / complications*,  drug therapy
Humans
Lymphocyte Activation*
Male
Middle Aged
Monocytes / immunology*
Grant Support
ID/Acronym/Agency:
K99 HL108743/HL/NHLBI NIH HHS; NR012642/NR/NINR NIH HHS; P30 AI36219/AI/NIAID NIH HHS; R01 NR012642/NR/NINR NIH HHS
Chemical
Reg. No./Substance:
0/Anti-Retroviral Agents; 0/Cholesterol, LDL
Comments/Corrections

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