| Markers of in vivo activation of coagulation. Interrelationships change with intensity of oral anticoagulation. | |
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MedLine Citation:
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PMID: 8602609 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Measures of markers of in vivo activation of coagulation were assessed in patients on stable long-term oral anticoagulant therapy and analyzed with respect to the International Normalized Ratio (INR). The range of F1+2, FPA, and antithrombin--enzyme complex results (ATM) were significantly lower as compared to normals. Plasmin-antiplasmin complexes were unaffected by anticoagulation. An inverse correlation was evident between F1+2, FPA, and INR values at low intensity anticoagulation, and FPA and complexed antithrombin were correlated at high INRs. The relative ratio of plasma FPA/F1+2 and ATM/F1+2 increased with increasing INR. In conclusion, the interrelationship of these measures changes with intensity of anticoagulation as measured by INR, and appears complex. The utility of using these measures for patient monitoring awaits future clinical trials. |
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Authors:
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S Solymoss; E G Bovill |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: American journal of clinical pathology Volume: 105 ISSN: 0002-9173 ISO Abbreviation: Am. J. Clin. Pathol. Publication Date: 1996 Mar |
Date Detail:
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Created Date: 1996-05-08 Completed Date: 1996-05-08 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 0370470 Medline TA: Am J Clin Pathol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 293-7 Citation Subset: AIM; IM |
Affiliation:
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Department of Medicine, St. Mary's Hospital Center, Montreal, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Adult Aged Aged, 80 and over Anticoagulants / administration & dosage, therapeutic use* Antithrombin III / analysis* Blood Coagulation* Fibrinolysin / analysis Fibrinopeptide A / analysis* Humans Middle Aged Peptide Fragments / analysis* Peptide Hydrolases / analysis* Prothrombin / analysis* Prothrombin Time* alpha-2-Antiplasmin / analysis |
| Chemical | |
Reg. No./Substance:
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0/Anticoagulants; 0/Peptide Fragments; 0/alpha-2-Antiplasmin; 0/antithrombin III-protease complex; 0/prothrombin fragment 1.2; 25422-31-5/Fibrinopeptide A; 9000-94-6/Antithrombin III; 9001-26-7/Prothrombin; EC 3.4.-/Peptide Hydrolases; EC 3.4.21.7/Fibrinolysin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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