Document Detail


Markers of in vivo activation of coagulation. Interrelationships change with intensity of oral anticoagulation.
MedLine Citation:
PMID:  8602609     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Measures of markers of in vivo activation of coagulation were assessed in patients on stable long-term oral anticoagulant therapy and analyzed with respect to the International Normalized Ratio (INR). The range of F1+2, FPA, and antithrombin--enzyme complex results (ATM) were significantly lower as compared to normals. Plasmin-antiplasmin complexes were unaffected by anticoagulation. An inverse correlation was evident between F1+2, FPA, and INR values at low intensity anticoagulation, and FPA and complexed antithrombin were correlated at high INRs. The relative ratio of plasma FPA/F1+2 and ATM/F1+2 increased with increasing INR. In conclusion, the interrelationship of these measures changes with intensity of anticoagulation as measured by INR, and appears complex. The utility of using these measures for patient monitoring awaits future clinical trials.
Authors:
S Solymoss; E G Bovill
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of clinical pathology     Volume:  105     ISSN:  0002-9173     ISO Abbreviation:  Am. J. Clin. Pathol.     Publication Date:  1996 Mar 
Date Detail:
Created Date:  1996-05-08     Completed Date:  1996-05-08     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0370470     Medline TA:  Am J Clin Pathol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  293-7     Citation Subset:  AIM; IM    
Affiliation:
Department of Medicine, St. Mary's Hospital Center, Montreal, Canada.
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Adult
Aged
Aged, 80 and over
Anticoagulants / administration & dosage,  therapeutic use*
Antithrombin III / analysis*
Blood Coagulation*
Fibrinolysin / analysis
Fibrinopeptide A / analysis*
Humans
Middle Aged
Peptide Fragments / analysis*
Peptide Hydrolases / analysis*
Prothrombin / analysis*
Prothrombin Time*
alpha-2-Antiplasmin / analysis
Chemical
Reg. No./Substance:
0/Anticoagulants; 0/Peptide Fragments; 0/alpha-2-Antiplasmin; 0/antithrombin III-protease complex; 0/prothrombin fragment 1.2; 25422-31-5/Fibrinopeptide A; 9000-94-6/Antithrombin III; 9001-26-7/Prothrombin; EC 3.4.-/Peptide Hydrolases; EC 3.4.21.7/Fibrinolysin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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