| Markers of hepatitis C and B virus infections among blood donors in Ho Chi Minh City and Hanoi, Vietnam. | |
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MedLine Citation:
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PMID: 8556478 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Blood donors in two cities in Vietnam were tested for markers of hepatitis C virus (HCV) and hepatitis B virus infections. Antibody to HCV was detected by passive hemagglutination with antigens of the second generation in 101 (20.6%) of 491 donors in Ho Chi Minh City; it was detected less frequently (P < 0.001) in donors in hanoi (4 [0.8%] of 499). HCV RNA was tested for in donors with antibody by PCR with nested primers from the 5'-noncoding region and detected in 79 donors in Ho Chi Minh City and 4 donors in Hanoi. HCV RNA was genotyped by PCR with type-specific primers from the core gene. Of 83 HCV carriers from Vietnam, 24 (29%) were infected with HCV of genotype I/1a 19 (23%) were infected with II/1b, 4 (5%) were infected with III/2a, and 2 (2%) were infected with mixed genotypes (I/1a and II/1b); HCV genotypes in the remaining 34 (41%) donors, including all 4 donors in Hanoi, were not classifiable into I/1a, II/2a, IV/2b, or V/3a. Of the 10 isolates with unclassifiable genotypes, 2 showed substantial sequence divergence within the 5'-noncoding region from reported isolates with known genotypes (I/1a to 6a). An analysis of part of the core gene sequence indicated that six of the remaining isolates most likely represented new HCV genotypes. Hepatitis B surface antigen and the corresponding antibody, respectively, were detected in 15 (3.1%) and 234 (47.7%) donors in Ho Chi Minh City as well as 15 (3.0%) and 248 (49.7%) donors in Hanoi. These results indicate an extensive spread of HCV among Ho Chi Minh City donors and HCV of novel genotypes in vietnam. |
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Authors:
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P Song; D D Duc; B Hien; S Nakata; T Chosa; J Watanabe; F Tsuda; K Murata; H Okamoto |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Clinical and diagnostic laboratory immunology Volume: 1 ISSN: 1071-412X ISO Abbreviation: Clin. Diagn. Lab. Immunol. Publication Date: 1994 Jul |
Date Detail:
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Created Date: 1996-02-23 Completed Date: 1996-02-23 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 9421292 Medline TA: Clin Diagn Lab Immunol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 413-8 Citation Subset: IM; X |
Affiliation:
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Institute for Clinical Research in Tropical Medicine, Bach Mai Hospital, Hanoi, Vietnam. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Age Factors Aged Base Sequence Biological Markers / blood Blood Donors* Female Genotype HIV / immunology Hepacivirus / genetics Hepatitis B / blood*, epidemiology, immunology* Hepatitis B Surface Antigens / immunology Hepatitis C / blood*, epidemiology, immunology* Hepatitis C Antigens / immunology Human T-lymphotropic virus 1 / immunology Humans Male Middle Aged Molecular Sequence Data Prevalence Seroepidemiologic Studies Vietnam / epidemiology |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Hepatitis B Surface Antigens; 0/Hepatitis C Antigens |
| Comments/Corrections | |
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