Document Detail


Markers of dopamine depletion and compensatory response in striatum and cerebrospinal fluid.
MedLine Citation:
PMID:  7605589     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Though depletion of CSF homovanillic acid (HVA) concentration has often been regarded as a direct indicator of dopamine (DA) deficiency in Parkinson's Disease (PD), CSF HVA is normal in mildly affected patients. To explore why, we measured DA and its metabolites in striatum and CSF in rabbits receiving reserpine for 5 days. Reserpine, which depletes striatal DA by disrupting vesicular storage of the neurotransmitter, results in a compensatory increase of DA turnover. In response to a 96% depletion of striatal DA, its catabolic intermediates 3,4-dihydroxyphenylacetic acid (DOPAC) and 3-methoxytyramine (3-MT) decreased 64% and 92% in striatum, although the endproduct, HVA, was unchanged. In contrast, CSF concentrations of HVA and DOPAC increased significantly, though 3-MT and levodopa (LD) were unaltered. A 5-fold rise in striatal LD concentration after reserpine-induced DA depletion provided evidence for enhanced DA synthesis. As in PD, the compensatory increase of DA synthesis after reserpine administration confounds the ability of CSF HVA to reflect DA depletion.
Authors:
D A Loeffler; P A LeWitt; A J DeMaggio; P L Juneau; P E Milbury; W R Matson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of neural transmission. Parkinson's disease and dementia section     Volume:  9     ISSN:  0936-3076     ISO Abbreviation:  J Neural Transm Park Dis Dement Sect     Publication Date:  1995  
Date Detail:
Created Date:  1995-08-16     Completed Date:  1995-08-16     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8914371     Medline TA:  J Neural Transm Park Dis Dement Sect     Country:  AUSTRIA    
Other Details:
Languages:  eng     Pagination:  45-53     Citation Subset:  IM    
Affiliation:
Clinical Neuroscience Center, Sinai Hospital, Wayne State University School of Medicine, Detroit, Michigan, USA.
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MeSH Terms
Descriptor/Qualifier:
3,4-Dihydroxyphenylacetic Acid / cerebrospinal fluid,  metabolism
Animals
Biological Markers
Corpus Striatum / drug effects,  metabolism*
Dopamine / biosynthesis,  cerebrospinal fluid,  metabolism*
Homovanillic Acid / metabolism
Levodopa / cerebrospinal fluid,  metabolism
Male
Parkinson Disease / cerebrospinal fluid,  metabolism
Rabbits
Reserpine / pharmacology
Grant Support
ID/Acronym/Agency:
R01-NS-27892/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Levodopa; 102-32-9/3,4-Dihydroxyphenylacetic Acid; 306-08-1/Homovanillic Acid; 50-55-5/Reserpine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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