Document Detail

Markers of dietary fat quality and fatty acid desaturation as predictors of total and cardiovascular mortality: a population-based prospective study.
MedLine Citation:
PMID:  18614742     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Desaturase indexes, as markers of endogenous fatty acid desaturation, and a characteristic serum fatty acid (FA) composition are related to cardiovascular and metabolic diseases, but the relation to mortality is poorly investigated. OBJECTIVE: The objective was to evaluate the relation between dietary fat biomarkers, desaturase indexes, and mortality. DESIGN: In this community-based prospective sample, 50-y-old men were followed for a maximum of 33.7 y. Cox proportional hazard analysis was conducted to investigate desaturase indexes (stearoyl-CoA-desaturase and Delta(6)- and Delta(5)-desaturase) and the relation of individual serum esterified fatty acids (FAs) in relation to total and cardiovascular mortality in the total study sample (n = 2009) and in a healthy subsample (n = 1885). Desaturase indexes were estimated as product-to-precursor FA ratios. RESULTS: During follow-up, 1012 men in the total sample died and 931 men in the healthy subsample died. Desaturase indexes predicted both total and cardiovascular mortality. The relations were independent of smoking status, physical activity, BMI, total cholesterol, and hypertension. The adjusted and standardized (per SD) hazard ratios (HRs) and 95% CIs for cardiovascular mortality were 1.15 (1.04, 1.27) for stearoyl-CoA-desaturase, 1.12 (1.0, 1.24) for Delta(6)-desaturase, and 0.88 (0.80, 0.98) for Delta(5)-desaturase, respectively. The proportion of serum linoleic acid was inversely related, whereas serum FAs associated with saturated fat intake (palmitic, palmitoleic, and dihomo-gamma-linolenic acids) were directly related to total and cardiovascular mortality. CONCLUSIONS: Altered endogenous FA desaturation might contribute to mortality risk because we observed independent associations between desaturase activity indexes and mortality. The proportion of linoleic acid was inversely related, and FAs reflecting saturated fat intake were directly related to mortality.
Eva Warensjö; Johan Sundström; Bengt Vessby; Tommy Cederholm; Ulf Risérus
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  88     ISSN:  1938-3207     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2008-07-10     Completed Date:  2008-07-31     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  203-9     Citation Subset:  AIM; IM    
Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden.
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MeSH Terms
Aged, 80 and over
Biological Markers / blood
Body Mass Index
Cardiovascular Diseases / epidemiology,  etiology,  mortality*
Cholesterol / blood
Cohort Studies
Dietary Fats / administration & dosage*,  adverse effects,  metabolism
Dietary Fats, Unsaturated / administration & dosage*,  metabolism
Exercise / physiology*
Fatty Acid Desaturases / metabolism*
Fatty Acids / blood*
Follow-Up Studies
Hypertension / complications,  epidemiology
Middle Aged
Predictive Value of Tests
Proportional Hazards Models
Prospective Studies
Risk Assessment
Risk Factors
Sweden / epidemiology
Reg. No./Substance:
0/Biological Markers; 0/Dietary Fats; 0/Dietary Fats, Unsaturated; 0/Fatty Acids; 57-88-5/Cholesterol; EC 1.14.19.-/Fatty Acid Desaturases

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