| Markers of 'cell senescence'. | |
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MedLine Citation:
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PMID: 9792198 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In the current literature cells that have finished their proliferative life span in vitro and have reached a terminal post-mitotic state are called senescent cells. This definition originated from the belief that the irreversible non-dividing state has a relationship with aging of the organism. Attempts have been made to find markers of the so-called senescent cell in order to detect their presence in vivo in donors of different ages. One marker which was supposed to demonstrate an increase of post-mitotic cells with aging is a marker of a long resting phase whether reversible or irreversible. Other markers suggest that the postmitotic cell does not increase with aging of the organism, that it is irrelevant for aging, that it is found in an increased number in pathology, and that the term senescent cell is a misnomer that should be used only in an operational manner. |
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Authors:
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A Macieira-Coelho |
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Publication Detail:
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Type: Corrected and Republished Article; Journal Article |
Journal Detail:
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Title: Mechanisms of ageing and development Volume: 104 ISSN: 0047-6374 ISO Abbreviation: Mech. Ageing Dev. Publication Date: 1998 Aug |
Date Detail:
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Created Date: 1999-01-07 Completed Date: 1999-01-07 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0347227 Medline TA: Mech Ageing Dev Country: IRELAND |
Other Details:
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Languages: eng Pagination: 207-11 Citation Subset: IM |
Affiliation:
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INSERM and University of Paris VI, Versailles, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Biological Markers Cell Aging / physiology* Cell Cycle / physiology Fibroblasts / cytology Humans Mitosis / physiology |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers |
| Comments/Corrections | |
Corrected and Republished From:
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Mech Ageing Dev. 1998 Jun 1;103(1):105-9
[PMID:
9681883
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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