Document Detail

Markers of thrombin generation during resurfacing and noncemented total hip arthroplasty: a pilot study.
MedLine Citation:
PMID:  21057987     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Hip resurfacing arthroplasty (HRA) could be associated with an increased risk of deep vein thrombosis (DVT) compared to traditional noncemented THA because it involves greater dissection, increased kinking and distortion of the femoral vessels, takes longer to perform, and involves insertion of some cement into the femur.
QUESTIONS/PURPOSES: Does HRA lead to greater risk of thromboembolism compared with noncemented THA?
METHODS: We prospectively studied 20 patients receiving HRA and 20 receiving THA. All patients were younger than 67 years old and were similar in height, weight, American Society of Anesthesiologists status, and gender mix. Patients undergoing HRA were younger (mean, 50 versus 59 years), their surgery was longer (mean, 87 versus 65 minutes), and they required more crystalloid during surgery (mean, 2160 versus 1662 mL). Radial artery blood samples were taken at six events during surgery and assayed for prothrombin fragment F1 + 2 and thrombin-antithrombin III complex (TAT) using enzyme-linked immunosorbent assays.
RESULTS: We observed no differences in the intraoperative increases in F1 + 2 and TAT between the two groups and no differences in surgical events.
CONCLUSION: Based on these data, HRA and THA should have similar risk of thromboembolism as THA based on the parameters we measured.
LEVEL OF EVIDENCE: Level I, diagnostic study. See Guidelines for Authors for a complete description of levels of evidence.
Edwin P Su; Nikos Chatzoudis; Vasileios Sioros; George Go; Nigel E Sharrock
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Clinical orthopaedics and related research     Volume:  469     ISSN:  1528-1132     ISO Abbreviation:  Clin. Orthop. Relat. Res.     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-01-11     Completed Date:  2011-02-24     Revised Date:  2013-07-03    
Medline Journal Info:
Nlm Unique ID:  0075674     Medline TA:  Clin Orthop Relat Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  535-40     Citation Subset:  AIM; IM    
Department of Orthopaedic Surgery, Hospital for Special Surgery, New York, NY 10021, USA.
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MeSH Terms
Arthroplasty, Replacement, Hip / adverse effects*
Biological Markers / metabolism
Blood Coagulation / physiology
Hip Prosthesis
Middle Aged
Pilot Projects
Postoperative Complications / blood,  etiology*
Prospective Studies
Prosthesis Failure*
Thrombin / biosynthesis*
Thromboembolism / blood,  etiology*
Reg. No./Substance:
0/Biological Markers; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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