Document Detail


Markers of Inflammation in Recipients of Continuous Flow Left Ventricular Assist Devices.
MedLine Citation:
PMID:  25232767     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Although the newer continuous flow left ventricular assist devices (CF-LVADs) provide clinical advantages over the pulsatile pumps, the effects of low pulsatility on inflammation are incompletely understood. The objective of our study was to examine the levels of inflammatory mediators in CF-LVAD recipients compared to both healthy controls and to heart failure patients who were candidates for CF-LVAD support. Plasma levels of chemokines, cytokines and inflammatory markers were measured in 18 CF-LVAD recipients and compared to those of 14 healthy controls and 14 heart failure patients who were candidates for CF-LVADs. The levels of GM-CSF, MIP-1β and MDC were significantly higher in the CF-LVAD group compared to both the heart failure and the healthy control groups, whereas no significant differences were observed between the healthy controls and the heart failure groups. Compared to healthy controls, CRP, IP-10, MCP-1 and IL-8 levels were significantly higher in both the CF-LVAD and heart failure groups, but no significant differences were observed between CF-LVAD recipients and heart failure patients. Inflammatory markers were elevated in CF-LVAD recipients compared to healthy controls and heart failure patients. Further studies should investigate the clinical implications of elevated levels of inflammation in CF-LVAD recipients.
Authors:
Liza Grosman-Rimon; Michael A McDonald; Ira Jacobs; Laura C Tumiati; Stacey Pollock Bar-Ziv; Daniel J Shogilev; Amelia G Mociornita; Arash Ghashghai; Andrzej Chruscinski; David Z I Cherney; Vivek Rao
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-9-17
Journal Detail:
Title:  ASAIO journal (American Society for Artificial Internal Organs : 1992)     Volume:  -     ISSN:  1538-943X     ISO Abbreviation:  ASAIO J.     Publication Date:  2014 Sep 
Date Detail:
Created Date:  2014-9-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9204109     Medline TA:  ASAIO J     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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