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Markers of chronic inflammation with short-term changes in physical activity.
MedLine Citation:
PMID:  20798662     Owner:  NLM     Status:  In-Data-Review    
PURPOSE: : Regular exercise is inversely related to markers of chronic inflammation, but we do not know to what extent these changes are the product of recent exercise behavior. The aim of the present investigation was to examine the stability of markers of chronic inflammation in the face of short-term positive and negative changes in physical activity in middle-aged men.
METHODS: : Two studies were conducted using a randomized counterbalanced design. In the first study (Study 1), eight highly active men (age = 56 ± 5 yr, body mass index (BMI) = 23.3 ± 3.2 kg·m, V˙O2max = 50.7 ± 7.0 mL·kg·min) undertook two trials; withdrawal of exercise for 1 wk versus control (normal exercise behavior). In the second study (Study 2), 10 sedentary men (age = 57 ± 2 yr, BMI = 27.9 ± 3.6 kg·m, V˙O2max = 30.4 ± 4.6 mL·kg·min) undertook 30 min of daily walking at 60% V˙O2max for 1 wk versus control (normal sedentary behavior).
RESULTS: : The withdrawal of exercise for 1 wk in highly active men (Study 1) and the imposition of 1 wk of daily exercise in sedentary men (Study 2) did not elicit any substantial changes in the inflammatory proteins C-reactive protein (CRP), IL-6, and TNF-α and circulating leukocyte concentration. The differences in inflammatory proteins between active (Study 1) and sedentary (Study 2) men were marked; for example, baseline CRP was 0.85 ± 0.79 and 3.02 ± 2.30 mg·L, respectively.
CONCLUSIONS: : The inflammatory markers CRP, IL-6, and TNF-α are stable and not affected by large short-term positive or negative alterations in exercise behavior. This stability strengthens the use of these markers in clinical and research settings because differences and changes are not simply the product of recent exercise behavior.
Adam J S Lund; Tina L Hurst; Rex M Tyrrell; Dylan Thompson
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Medicine and science in sports and exercise     Volume:  43     ISSN:  1530-0315     ISO Abbreviation:  Med Sci Sports Exerc     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-03-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8005433     Medline TA:  Med Sci Sports Exerc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  578-83     Citation Subset:  IM; S    
1Department for Health, University of Bath, Bath, UNITED KINGDOM; 2Unilever Discover, Colworth Park, Sharnbrook, Bedfordshire, UNITED KINGDOM; and 3Department of Pharmacy & Pharmacology, University of Bath, Bath, UNITED KINGDOM.
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