Document Detail

'Marker-of-self' functionalization of nanoscale particles through a top-down cellular membrane coating approach.
MedLine Citation:
PMID:  23462967     Owner:  NLM     Status:  MEDLINE    
We investigate the 'marker-of-self' functionalization of nanoparticles through coating of natural RBC membranes. The membrane translocation approach is shown to be highly efficient and bestows nanoparticles with correctly oriented and functional immunomodulatory proteins such as CD47 at equivalent density to natural RBCs.
Che-Ming J Hu; Ronnie H Fang; Brian T Luk; Kevin N H Chen; Cody Carpenter; Weiwei Gao; Kang Zhang; Liangfang Zhang
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Nanoscale     Volume:  5     ISSN:  2040-3372     ISO Abbreviation:  Nanoscale     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-03-15     Completed Date:  2013-10-24     Revised Date:  2014-05-07    
Medline Journal Info:
Nlm Unique ID:  101525249     Medline TA:  Nanoscale     Country:  England    
Other Details:
Languages:  eng     Pagination:  2664-8     Citation Subset:  IM    
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MeSH Terms
Antigens, CD47 / analysis,  metabolism
Biological Markers / analysis*
Biomedical Engineering / methods
Coated Materials, Biocompatible / chemical synthesis,  chemistry*
Erythrocyte Membrane / chemistry,  metabolism*,  physiology
Hydrogen Bonding
Hydrophobic and Hydrophilic Interactions
Lactic Acid / chemistry
Macrophages / metabolism
Nanoparticles / chemistry*
Polyglycolic Acid / chemistry
Grant Support
Reg. No./Substance:
0/Antigens, CD47; 0/Biological Markers; 0/Cd47 protein, mouse; 0/Coated Materials, Biocompatible; 0/polylactic acid-polyglycolic acid copolymer; 26009-03-0/Polyglycolic Acid; 33X04XA5AT/Lactic Acid

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