| Marker-free lung tumor trajectory estimation from a cone beam CT sinogram. | |
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MedLine Citation:
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PMID: 20393238 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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An algorithm was developed to estimate the 3D lung tumor position using the projection data forming a cone beam CT sinogram and a template registration method. A pre-existing respiration-correlated CT image was used to generate templates of the target, which were then registered to the individual cone beam CT projections, and estimates of the target position were made for each projection. The registration search region was constrained based on knowledge of the mean tumor position during the cone beam CT scan acquisition. Several template registration algorithms were compared, including correlation coefficient and robust methods such as block correlation, robust correlation coefficient and robust gradient correlation. Robust registration metrics were found to be less sensitive to occlusions such as overlying tissue and the treatment couch. The mean accuracy of the position estimation was 1.4 mm in phantom with a robust registration algorithm. In two research subjects with peripheral tumors, the mean position and mean target excursion were estimated to within 2.0 mm compared to the results obtained with a '4D' registration of 4D image volumes. |
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Authors:
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Geoffrey D Hugo; Jian Liang; Di Yan |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2010-04-14 |
Journal Detail:
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Title: Physics in medicine and biology Volume: 55 ISSN: 1361-6560 ISO Abbreviation: Phys Med Biol Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-04-19 Completed Date: 2010-07-01 Revised Date: 2011-07-28 |
Medline Journal Info:
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Nlm Unique ID: 0401220 Medline TA: Phys Med Biol Country: England |
Other Details:
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Languages: eng Pagination: 2637-50 Citation Subset: IM |
Affiliation:
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Department of Radiation Oncology, Virginia Commonwealth University, Richmond, VA, USA. gdhugo@vcu.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cone-Beam Computed Tomography
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methods*,
standards Humans Imaging, Three-Dimensional Lung Neoplasms / radiography* Phantoms, Imaging Reference Standards |
| Grant Support | |
ID/Acronym/Agency:
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R01 CA116249/CA/NCI NIH HHS; R01 CA116249-03/CA/NCI NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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