Document Detail

Markedly upregulated serum interleukin-12 as a novel biomarker in POEMS syndrome.
MedLine Citation:
PMID:  22843279     Owner:  NLM     Status:  Publisher    
OBJECTIVE:To systematically study abnormalities in cytokine profiles in polyneuropathy, organomegaly, endocrinopathy, M-protein, and skin changes (POEMS) syndrome, which has been increasingly recognized as a cause of demyelinating neuropathy associated with plasma cell dyscrasia and elevated serum level of vascular endothelial growth factor (VEGF). METHODS:In this case-control study, we measured serum levels of 27 cytokines in patients with POEMS syndrome using a multiplex suspension array system, and compared them with those of controls. In 10 patients, serial changes after treatment were analyzed. RESULTS:Interleukin (IL)-12 as well as VEGF levels were markedly increased (p < 0.0001) in all the patients (n = 23). Ten kinds of other proinflammatory cytokines such as IL-6 and tumor necrosis factor-α were also significantly increased in the POEMS syndrome group, but in some patients the serum levels of such cytokines remained within the normal ranges. After treatments, the IL-12 as well as VEGF levels significantly decreased with clinical improvements (p > 0.01 and p > 0.05, respectively). CONCLUSIONS:Our findings suggest that serum IL-12 is a biomarker of the disease activity in POEMS syndrome. The overproduction of IL-12, as well as VEGF, is likely to play an important role in the pathogenesis of the disorder, and could contribute to the peripheral nerve demyelination in POEMS syndrome.
Kazuaki Kanai; Setsu Sawai; Kazuyuki Sogawa; Masahiro Mori; Sonoko Misawa; Kazumoto Shibuya; Sagiri Isose; Yumi Fujimaki; Yuichi Noto; Yukari Sekiguchi; Saiko Nasu; Chiaki Nakaseko; Shigetsugu Takano; Hideyuki Yoshitomi; Masaru Miyazaki; Fumio Nomura; Satoshi Kuwabara
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-7-25
Journal Detail:
Title:  Neurology     Volume:  -     ISSN:  1526-632X     ISO Abbreviation:  -     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-7-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0401060     Medline TA:  Neurology     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
From the Departments of Neurology (K.K., M. Mori, S.M., K. Shibuya, S.I., Y.F., Y.N., Y.S., S.N., S.K.), Molecular Diagnosis (S.S., K. Sogawa, F.N.), Haematology (C.N.), and General Surgery (S.T., H.Y., M. Miyazaki), Graduate School of Medicine, Chiba University, Chiba; and Department of Neurology (K.K.), Graduate School of Medicine, Juntendo University School of Medicine, Tokyo, Japan. Dr. Kanai is currently with the Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan.
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