Document Detail


Markedly elevated plasma myeloperoxidase protein in patients with pelvic inflammatory disease who have A allele myeloperoxidase gene polymorphism.
MedLine Citation:
PMID:  19147137     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To compared the plasma levels and the genetic polymorphism of myeloperoxidase in patients with pelvic inflammatory disease (PID) and healthy controls. DESIGN: A random consecutive study. SETTING: University hospital. PATIENT(S): Forty-four women who were diagnosed with PID. INTERVENTION(S): Collected blood specimens of patients before and after they received treatment. MAIN OUTCOME MEASURE(S): ELISA and polymerase chain reaction-restriction fragment length polymorphism were respectively used to measure the plasma levels and genetic polymorphism of myeloperoxidase. RESULT(S): We found the plasma level of myeloperoxidase was elevated in PID patients compared with that in normal controls and decreased significantly compared with that in the same patients after they received treatment. PID patients with myeloperoxidase G/A alleles significantly tended to have elevated plasma concentration of myeloperoxidase, whereas PID patients with G/G homozygous alleles did not. CONCLUSION(S): Elevated expression of myeloperoxidase may be involved in the pathogenesis of PID and could be useful for the diagnosis of PID. Furthermore, G/A alleles of myeloperoxidase may contribute to such elevation in PID patients.
Authors:
Shun-An Lee; Po-Hui Wang; Hui-Ling Chiou; Ming-Chin Chou; Hsiu-Ting Tsai; Shun-Fa Yang
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Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial     Date:  2009-01-14
Journal Detail:
Title:  Fertility and sterility     Volume:  93     ISSN:  1556-5653     ISO Abbreviation:  Fertil. Steril.     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-03-01     Completed Date:  2010-04-01     Revised Date:  2010-08-09    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1260-6     Citation Subset:  IM    
Copyright Information:
Copyright 2010 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
Affiliation:
Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan, Republic of China.
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MeSH Terms
Descriptor/Qualifier:
Adenine*
Alleles*
Biological Markers / blood
Case-Control Studies
Female
Gene Expression Regulation, Enzymologic*
Humans
Pelvic Inflammatory Disease / blood,  enzymology*,  genetics*
Peroxidase / biosynthesis*,  blood,  genetics*
Polymorphism, Genetic / genetics*
Chemical
Reg. No./Substance:
0/Biological Markers; 73-24-5/Adenine; EC 1.11.1.7/Peroxidase
Comments/Corrections
Erratum In:
Fertil Steril. 2010 Aug;94(3):1172

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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