| Marked variability in hepatic expression of cytochromes CYP7A1 and CYP27A1 as compared to cerebral CYP46A1. Lessons from a dietary study with omega 3 fatty acids in hamsters. | |
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MedLine Citation:
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PMID: 20298807 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Two diets simulating the recommendations of the American Heart Association to increase the intake of n-3 polyunsaturated fatty acids (n-3 PUFAs) were tested on Golden Syrian hamsters and compared to the diet simulating the current estimated consumption of fat in the United States. N-3 PUFAs were evaluated for their effects on serum and brain lipids and on the three cytochrome P450 enzymes (CYPs 7A1, 27A1, and 46A1) that play key roles in cholesterol elimination from different organs. Hamsters on the highest concentration of n-3 PUFAs had a statistically significant decrease in LDL and HDL cholesterol and no change in serum total cholesterol and triglycerides levels. CYP27A1 and CYP46A1 mRNA levels were increased in the liver and brain, respectively, whereas possible effects on CYP7A1 were obscured by a marked intergroup variability at mRNA, protein, and sterol product levels. Increased levels of CYP46A1 mRNA in the brain did not lead to significant changes in the levels of lathosterol, 24S-hydroxycholesterol or cholesterol in this organ. The data obtained are discussed in relation to inconsistent effects of n-3 PUFAs on serum lipids in human trials and reported positive effects of fish oil on cognitive function. |
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Authors:
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Natalia Mast; Marjan Shafaati; Wahiduz Zaman; Wenchao Zheng; Deborah Prusak; Thomas Wood; G A S Ansari; Anita Lövgren-Sandblom; Maria Olin; Ingemar Bjorkhem; Irina Pikuleva |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2010-03-16 |
Journal Detail:
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Title: Biochimica et biophysica acta Volume: 1801 ISSN: 0006-3002 ISO Abbreviation: Biochim. Biophys. Acta Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-04-19 Completed Date: 2010-06-24 Revised Date: 2011-07-28 |
Medline Journal Info:
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Nlm Unique ID: 0217513 Medline TA: Biochim Biophys Acta Country: Netherlands |
Other Details:
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Languages: eng Pagination: 674-81 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2010 Elsevier B.V. All rights reserved. |
Affiliation:
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Department of Ophthalmology and Visual Sciences, Case Western Reserve University, Cleveland, OH, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Base Sequence Cloning, Molecular Cricetinae Cytochrome P-450 Enzyme System / genetics, metabolism* DNA Primers Fatty Acids, Omega-3 / pharmacology* Gas Chromatography-Mass Spectrometry Isoenzymes / genetics, metabolism* Liver / enzymology* Male Mesocricetus Microsomes, Liver / enzymology* |
| Grant Support | |
ID/Acronym/Agency:
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AG024336/AG/NIA NIH HHS; ES06676/ES/NIEHS NIH HHS; EY018383/EY/NEI NIH HHS; K02 AG024336-06/AG/NIA NIH HHS; R01 EY018383-04/EY/NEI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/DNA Primers; 0/Fatty Acids, Omega-3; 0/Isoenzymes; 9035-51-2/Cytochrome P-450 Enzyme System |
| Comments/Corrections | |
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