| Marked shrinkage of amyloid lymphadenopathy after an intensive chemotherapy in a patient with IgM-associated AL amyloidosis. | |
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MedLine Citation:
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PMID: 19590992 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A male patient with primary AL amyloidosis who had been suffering from systemic lymphadenopathy with IgMkappa-type M-proteinemia received two courses of VAD and high-dose melphalan with in vivo elimination of CD20(+) cells using rituximab followed by autologous peripheral blood stem cell transplantation. Four years after complete hematological remission he showed marked reduction in size of the amyloid-laden lymph nodes. Deposits of AL amyloid may regress from the tissue if the chemotherapy succeeds in persistent inhibition of the production of amyloidogenic immunoglobulin light chains. |
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Authors:
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Ko-Ichi Tazawa; Nagaaki Katoh; Yasuhiro Shimojima; Masayuki Matsuda; Shu-Ichi Ikeda |
Publication Detail:
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Type: Case Reports; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis Volume: 16 ISSN: 1744-2818 ISO Abbreviation: Amyloid Publication Date: 2009 |
Date Detail:
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Created Date: 2010-06-11 Completed Date: 2010-09-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9433802 Medline TA: Amyloid Country: England |
Other Details:
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Languages: eng Pagination: 183-5 Citation Subset: IM |
Affiliation:
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Department of Medicine, Shinshu University School of Medicine, Matsumoto, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Amyloidosis
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blood,
drug therapy*,
immunology,
pathology* Antineoplastic Agents, Alkylating / therapeutic use Humans Immunoglobulin M / blood Lymph Nodes / pathology, radiography Lymphatic Diseases / blood, drug therapy*, immunology, pathology* Male Melphalan / therapeutic use Middle Aged |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents, Alkylating; 0/Immunoglobulin M; 148-82-3/Melphalan |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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