Document Detail

Marked pericardial inhomogeneity of specific ventilation at total lung capacity and beyond.
MedLine Citation:
PMID:  19664729     Owner:  NLM     Status:  MEDLINE    
We measured regional ventilation at 1l above functional residual capacity (FRC+1L) and total lung capacity (TLC) in three normal subjects and four elite breath-hold divers, and above TLC after glossopharyngeal insufflation (TLC+GI) in the divers. Hyperpolarized (3)He MRI was used to map the local ventilation per unit volume over the entire lung. At TLC and above, there was markedly increased regional ventilation of the lungs in the pericardial region compared with the relatively uniform ventilation throughout the rest of the lung. The distribution of fractional ventilation regionally was relatively uniform at FRC+1L, with a small non-gravitational cephalocaudal gradient of specific ventilation in the supine posture. Our observations at high lung volumes are consistent with the effect of high pleural tension in the concave pericardial region, which promotes expansion of the subjacent lung, leading to a higher local effective compliance and a higher specific ventilation.
Yanping Sun; James P Butler; Peter Lindholm; Ronn P Walvick; Stephen H Loring; Jessica Gereige; Massimo Ferrigno; Mitchell S Albert
Related Documents :
3277499 - Elastic behavior of the transplanted lung. exponential analysis of static pressure-volu...
5500999 - Afferent vagal fibres with an expiratory discharge in the rabbit.
8887589 - Comparison of static and dynamic intrinsic positive end-expiratory pressure using the c...
9412569 - Influence of driving pressure on raised-volume forced expiration in infants.
7263439 - Correlation between lung structure and function in a canine model of emphysema.
935699 - Effect of negative abdominal pressure on regional lung volumes in supine dogs.
7876659 - Contrast echocardiography of the left ventricle an independent predictor of pulmonary a...
16403689 - Blood pressure variability and white matter hyperintensities in older adults with cardi...
15235979 - Hemodynamic effects of high-frequency jet ventilation in dogs with acute right coronary...
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2009-08-05
Journal Detail:
Title:  Respiratory physiology & neurobiology     Volume:  169     ISSN:  1878-1519     ISO Abbreviation:  Respir Physiol Neurobiol     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-10-05     Completed Date:  2009-12-09     Revised Date:  2013-06-02    
Medline Journal Info:
Nlm Unique ID:  101140022     Medline TA:  Respir Physiol Neurobiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  44-9     Citation Subset:  IM    
Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, United States.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Analysis of Variance
Diving / physiology*
Functional Residual Capacity / physiology
Helium / diagnostic use
Isotopes / diagnostic use
Lung / anatomy & histology,  physiology*
Magnetic Resonance Imaging / methods
Respiratory Mechanics / physiology*
Total Lung Capacity / physiology*
Young Adult
Grant Support
Reg. No./Substance:
0/Isotopes; 7440-59-7/Helium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Attenuated phrenic long-term facilitation in orexin neuron-ablated mice.
Next Document:  Increase of fibrin gel elasticity by enzymes: A kinetic approach.