Document Detail

Marked pericardial inhomogeneity of specific ventilation at total lung capacity and beyond.
MedLine Citation:
PMID:  19664729     Owner:  NLM     Status:  MEDLINE    
We measured regional ventilation at 1l above functional residual capacity (FRC+1L) and total lung capacity (TLC) in three normal subjects and four elite breath-hold divers, and above TLC after glossopharyngeal insufflation (TLC+GI) in the divers. Hyperpolarized (3)He MRI was used to map the local ventilation per unit volume over the entire lung. At TLC and above, there was markedly increased regional ventilation of the lungs in the pericardial region compared with the relatively uniform ventilation throughout the rest of the lung. The distribution of fractional ventilation regionally was relatively uniform at FRC+1L, with a small non-gravitational cephalocaudal gradient of specific ventilation in the supine posture. Our observations at high lung volumes are consistent with the effect of high pleural tension in the concave pericardial region, which promotes expansion of the subjacent lung, leading to a higher local effective compliance and a higher specific ventilation.
Yanping Sun; James P Butler; Peter Lindholm; Ronn P Walvick; Stephen H Loring; Jessica Gereige; Massimo Ferrigno; Mitchell S Albert
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2009-08-05
Journal Detail:
Title:  Respiratory physiology & neurobiology     Volume:  169     ISSN:  1878-1519     ISO Abbreviation:  Respir Physiol Neurobiol     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-10-05     Completed Date:  2009-12-09     Revised Date:  2013-06-02    
Medline Journal Info:
Nlm Unique ID:  101140022     Medline TA:  Respir Physiol Neurobiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  44-9     Citation Subset:  IM    
Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, United States.
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MeSH Terms
Analysis of Variance
Diving / physiology*
Functional Residual Capacity / physiology
Helium / diagnostic use
Isotopes / diagnostic use
Lung / anatomy & histology,  physiology*
Magnetic Resonance Imaging / methods
Respiratory Mechanics / physiology*
Total Lung Capacity / physiology*
Young Adult
Grant Support
Reg. No./Substance:
0/Isotopes; 7440-59-7/Helium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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