| Marked pericardial inhomogeneity of specific ventilation at total lung capacity and beyond. | |
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MedLine Citation:
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PMID: 19664729 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We measured regional ventilation at 1l above functional residual capacity (FRC+1L) and total lung capacity (TLC) in three normal subjects and four elite breath-hold divers, and above TLC after glossopharyngeal insufflation (TLC+GI) in the divers. Hyperpolarized (3)He MRI was used to map the local ventilation per unit volume over the entire lung. At TLC and above, there was markedly increased regional ventilation of the lungs in the pericardial region compared with the relatively uniform ventilation throughout the rest of the lung. The distribution of fractional ventilation regionally was relatively uniform at FRC+1L, with a small non-gravitational cephalocaudal gradient of specific ventilation in the supine posture. Our observations at high lung volumes are consistent with the effect of high pleural tension in the concave pericardial region, which promotes expansion of the subjacent lung, leading to a higher local effective compliance and a higher specific ventilation. |
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Authors:
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Yanping Sun; James P Butler; Peter Lindholm; Ronn P Walvick; Stephen H Loring; Jessica Gereige; Massimo Ferrigno; Mitchell S Albert |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S. Date: 2009-08-05 |
Journal Detail:
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Title: Respiratory physiology & neurobiology Volume: 169 ISSN: 1878-1519 ISO Abbreviation: Respir Physiol Neurobiol Publication Date: 2009 Oct |
Date Detail:
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Created Date: 2009-10-05 Completed Date: 2009-12-09 Revised Date: 2010-12-03 |
Medline Journal Info:
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Nlm Unique ID: 101140022 Medline TA: Respir Physiol Neurobiol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 44-9 Citation Subset: IM |
Affiliation:
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Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, United States. yanping.sun@umassmed.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Analysis of Variance Diving / physiology* Female Functional Residual Capacity / physiology Helium / diagnostic use Humans Isotopes / diagnostic use Lung / anatomy & histology, physiology* Magnetic Resonance Imaging / methods Male Respiratory Mechanics / physiology* Total Lung Capacity / physiology* Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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R33 EB001689-05/EB/NIBIB NIH HHS; R33-EB001689/EB/NIBIB NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Isotopes; 7440-59-7/Helium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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