Document Detail

Marked mitochondrial alterations upon starvation without cell death, caspases or Bcl-2 family members.
MedLine Citation:
PMID:  18652851     Owner:  NLM     Status:  MEDLINE    
Dictyostelium HMX44A cells can withstand starvation under monolayer conditions for a few days without dying. They die only when the differentiation factor DIF-1 is exogenously added. Still, when HMX44A were subjected to starvation without addition of DIF-1 they showed, by electron microscopy and electron tomography, gross mitochondrial lesions including marked cristae alterations with frequent "holes" probably originating from dilated cristae. Since these cells did not die as shown for instance by FACS analysis, these results showed unexpected resilience of cells bearing markedly altered mitochondria, and thus showed that apparently destructive mitochondrial alterations may not lead to cell death. Also, these marked mitochondrial lesions could not be caused by caspases or bcl-2 family members, which these cells do not encode.
Artemis Kosta; Marie-Françoise Luciani; Willie J C Geerts; Pierre Golstein
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-06-27
Journal Detail:
Title:  Biochimica et biophysica acta     Volume:  1783     ISSN:  0006-3002     ISO Abbreviation:  Biochim. Biophys. Acta     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-09-09     Completed Date:  2008-11-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0217513     Medline TA:  Biochim Biophys Acta     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  2013-9     Citation Subset:  IM    
Centre d'Immunologie de Marseille-Luminy (CIML), Aix-Marseille Université, Faculté des Sciences de Luminy, Marseille F-13288, France.
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MeSH Terms
Caspases / metabolism
Cell Death
Cells, Cultured
Culture Media
Dictyostelium / cytology*,  enzymology,  metabolism
Microscopy, Electron
Mitochondria / metabolism*,  pathology*,  ultrastructure
Proto-Oncogene Proteins c-bcl-2 / metabolism
Reg. No./Substance:
0/Culture Media; 0/Proto-Oncogene Proteins c-bcl-2; EC 3.4.22.-/Caspases

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