Document Detail

Marked for life? Effects of early cage-cleaning frequency, delivery batch, and identification tail-marking on rat anxiety profiles.
MedLine Citation:
PMID:  18335494     Owner:  NLM     Status:  MEDLINE    
Daily handling of preweanling rats reduces their adult anxiety. Even routine cage-cleaning, involving handling, reduces adult anxiety compared with controls. Cage-cleaning regimes differ between animal breeders, potentially affecting rodent anxiety and experimental results. Here, 92 adult male rats given different cage-cleaning rates as pups, were compared on plus-maze, hyponeophagia, corticosterone, and handling tests. They were pair-housed and half were tail-marked for identification. Anxiety/stress profiles were unaffected by cage-cleaning frequency, suggesting that commercial-typical differences in husbandry contribute little variance to adult rat behavior. However, delivery batch affected some elevated plus-maze measures. Also, tail-marked rats spent three times longer on the plus-maze open arms than their unmarked cagemates, suggesting reduced anxiety, yet paradoxically they showed greater chromodacryorrhoea responses to handling, implying increased aversion to human contact. A follow-up study showed that rats avoided the odor released from the marker pen used. Thus, apparently trivial aspects of procedure can greatly affect experimental results.
Charlotte C Burn; Robert M J Deacon; Georgia J Mason
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Developmental psychobiology     Volume:  50     ISSN:  1098-2302     ISO Abbreviation:  Dev Psychobiol     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-03-17     Completed Date:  2008-04-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0164074     Medline TA:  Dev Psychobiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  266-77     Citation Subset:  IM    
Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, UK.
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MeSH Terms
Adaptation, Psychological
Animal Husbandry
Animals, Newborn
Anxiety / physiopathology,  psychology*
Arousal / physiology
Avoidance Learning
Corticosterone / blood
Feeding Behavior / physiology
Handling (Psychology)*
Maze Learning
Rats, Wistar
Social Environment*
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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