Document Detail


Marked for life? Effects of early cage-cleaning frequency, delivery batch, and identification tail-marking on rat anxiety profiles.
MedLine Citation:
PMID:  18335494     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Daily handling of preweanling rats reduces their adult anxiety. Even routine cage-cleaning, involving handling, reduces adult anxiety compared with controls. Cage-cleaning regimes differ between animal breeders, potentially affecting rodent anxiety and experimental results. Here, 92 adult male rats given different cage-cleaning rates as pups, were compared on plus-maze, hyponeophagia, corticosterone, and handling tests. They were pair-housed and half were tail-marked for identification. Anxiety/stress profiles were unaffected by cage-cleaning frequency, suggesting that commercial-typical differences in husbandry contribute little variance to adult rat behavior. However, delivery batch affected some elevated plus-maze measures. Also, tail-marked rats spent three times longer on the plus-maze open arms than their unmarked cagemates, suggesting reduced anxiety, yet paradoxically they showed greater chromodacryorrhoea responses to handling, implying increased aversion to human contact. A follow-up study showed that rats avoided the odor released from the marker pen used. Thus, apparently trivial aspects of procedure can greatly affect experimental results.
Authors:
Charlotte C Burn; Robert M J Deacon; Georgia J Mason
Related Documents :
15697194 - Eradication of syphacia muris from food-restricted rats without environmental decontami...
6519654 - Dihydrotestosterone activates male mating behavior in castrated king-holtzman rats.
1159114 - Vaginal stimulation in rats induces prolonged lordosis responsiveness and sexual recept...
21383544 - Beyond knockout rats: new insights into finer genome manipulation in rats.
6662154 - Axo-axonic synapses in the rat striatum.
2893594 - Production of lactate and tissue plasminogen activator in vitro by seminiferous tubules...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Developmental psychobiology     Volume:  50     ISSN:  1098-2302     ISO Abbreviation:  Dev Psychobiol     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-03-17     Completed Date:  2008-04-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0164074     Medline TA:  Dev Psychobiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  266-77     Citation Subset:  IM    
Affiliation:
Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, UK. charlotte.burn@worcester.oxon.org
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adaptation, Psychological
Animal Husbandry
Animals
Animals, Newborn
Anxiety / physiopathology,  psychology*
Arousal / physiology
Avoidance Learning
Corticosterone / blood
Feeding Behavior / physiology
Handling (Psychology)*
Male
Maze Learning
Odors
Rats
Rats, Wistar
Social Environment*
Weaning
Chemical
Reg. No./Substance:
50-22-6/Corticosterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Physiological responses to social and cognitive challenges in 8-year olds with a history of prenatal...
Next Document:  Development of object concepts in macaque monkeys.