Document Detail


Marked individual variability in the levels of trimethylselenonium ion in human urine determined by HPLC/ICPMS and HPLC/vapor generation/ICPMS.
MedLine Citation:
PMID:  17061074     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Selenium species were determined using HPLC/ICPMS and HPLC/vapor generation/ICPMS in the urine from seven human volunteers investigated at background selenium concentrations and at slightly elevated concentrations after ingestion of 200 microg Se as a selenite supplement. Trimethylselenonium ion (TMSe) was present, together with selenosugars, in the urine samples, a result that dispels recent doubts about its possible previous misidentification with a cationic selenosugar. Although TMSe was present as only a trace metabolite in urine from five of the seven volunteers (0.02-0.28 microg Se/L, equivalent to 1-5% of the sum of selenosugars and TMSe), it was a significant metabolite (up to 4.6 microg Se/L, 22%) in one volunteer, and it was the major identified metabolite (up to 15 microg Se/L, 53%) in another volunteer. This marked individual variability in the formation of TMSe was maintained in a duplicate investigation of urine from the same seven volunteers.
Authors:
Doris Kuehnelt; Dijana Juresa; Norbert Kienzl; Kevin A Francesconi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-10-24
Journal Detail:
Title:  Analytical and bioanalytical chemistry     Volume:  386     ISSN:  1618-2642     ISO Abbreviation:  Anal Bioanal Chem     Publication Date:  2006 Dec 
Date Detail:
Created Date:  2006-11-20     Completed Date:  2007-01-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101134327     Medline TA:  Anal Bioanal Chem     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  2207-12     Citation Subset:  IM    
Affiliation:
Division of Analytical Chemistry, Institute of Chemistry, Karl-Franzens University Graz, Universitätsplatz 1, 8010, Graz, Austria. doris.kuehnelt@uni-graz.at
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MeSH Terms
Descriptor/Qualifier:
Adult
Chromatography, High Pressure Liquid / methods*
Female
Humans
Ions / chemistry
Male
Mass Spectrometry / methods*
Middle Aged
Molecular Structure
Selenium / urine
Selenium Compounds / chemistry*,  urine*
Volatilization
Chemical
Reg. No./Substance:
0/Ions; 0/Selenium Compounds; 25930-79-4/trimethylselenonium; 7782-49-2/Selenium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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