| Marked increase in cerebrospinal fluid glial fibrillar acidic protein in neuromyelitis optica: an astrocytic damage marker. | |
| | |
MedLine Citation:
|
PMID: 19372295 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Neuromyelitis optica (NMO) is a neurological inflammatory disease associated with autoimmunity to aquaporin 4, predominantly localised in astrocytic foot processes. Recent studies have revealed that loss of aquaporin 4 and glial fibrillar acidic protein (GFAP) is a prominent feature of NMO lesions, suggesting astrocytic impairment. OBJECTIVE: To reveal a useful clinical biomarker of NMO. METHODS: Enzyme-linked immunosorbent assays were carried out for astrocytic markers GFAP and S100B in CSFs, obtained from the patients with NMO (n = 10) and multiple sclerosis (MS) (n = 10) manifesting acute myelitis, acute disseminated encephalomyelitis (ADEM) (n = 3), spinal infarction (n = 3), and other neurological diseases (OND) (n = 5). RESULTS: The CSF-GFAP levels during relapse in NMO (7666.0 (SD 15 266.5) ng/ml) were significantly over several thousand times higher than those in MS (0.7 (1.5)) or OND (0.6 (0.3)), and considerably higher than those in spinal infarction (354.7 (459.0)) and ADEM (0.4 (0.2)). They returned close to normal levels along with clinical improvement soon after corticosteroid therapy in NMO. There were strong correlations between the CSF-GFAP or S100B levels and expanded disability status scales or spinal lesion length in NMO (r>0.9). CONCLUSIONS: CSF-GFAP and S100B may be clinically useful biomarkers in NMO, and astrocytic damage is strongly suggested in the acute phase of NMO. |
| | |
Authors:
|
T Misu; R Takano; K Fujihara; T Takahashi; S Sato; Y Itoyama |
Related Documents
:
|
6644315 - Csf and plasma vasopressin concentrations in dementia. 7530405 - Combination therapy with recombinant human granulocyte colony-stimulating factor and er... 501385 - Fibrin degradation products in the cerebrospinal fluid of patients with pneumococcal me... 19679415 - The axonal damage marker tau protein in the cerebrospinal fluid is increased in patient... 833305 - Intellectual and personality changes associated with carotid endarterectomy. 8469325 - T2 relaxation time in patients with parkinson's disease. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Journal of neurology, neurosurgery, and psychiatry Volume: 80 ISSN: 1468-330X ISO Abbreviation: J. Neurol. Neurosurg. Psychiatr. Publication Date: 2009 May |
Date Detail:
|
Created Date: 2009-04-17 Completed Date: 2009-05-08 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 2985191R Medline TA: J Neurol Neurosurg Psychiatry Country: England |
Other Details:
|
Languages: eng Pagination: 575-7 Citation Subset: IM |
Affiliation:
|
Department of Neurology, Tohoku University Graduate School of Medicine, Aobaku, Sendai, Japan. misu@em.neurol.med.tohoku.ac.jp |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Aquaporin 4 / genetics Astrocytes / pathology* Biological Markers Encephalomyelitis, Acute Disseminated / cerebrospinal fluid Enzyme-Linked Immunosorbent Assay Female Glial Fibrillary Acidic Protein / cerebrospinal fluid* Humans Male Middle Aged Neuromyelitis Optica / cerebrospinal fluid* S100 Proteins / cerebrospinal fluid Spinal Cord / pathology |
| Chemical | |
Reg. No./Substance:
|
0/Aquaporin 4; 0/Biological Markers; 0/Glial Fibrillary Acidic Protein; 0/S100 Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Somatosensory processing in a German family with PINK1 mutations: its potential role in Parkinson di...
Next Document: Transpulmonary passage of 99mTc macroaggregated albumin in healthy humans at rest and during maximal...