| Marked elevation of serum macrophage migration inhibitory factor levels in patients with pemphigus vulgaris. | |
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MedLine Citation:
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PMID: 19799642 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: There is ample evidence for involvement of macrophage migration inhibitory factor (MIF) in autoimmune and inflammatory diseases. OBJECTIVE: The aim of this study was to determine whether MIF levels were raised in the sera of patients with pemphigus vulgaris (PV). METHODS: Serum MIF levels were measured using ELISA method in 22 patients with active PV and 21 age- and sex-matched healthy controls and the results were compared with each other. RESULTS: The mean serum MIF levels was significantly higher in PV patients than in control subjects (11.99 +/- 1.63 pg/m vs. 1.83 +/- 0.22 pg/ml; P-value = 0.0001). CONCLUSIONS: Elevated MIF levels in the sera of PV patients could participate in disease induction by activation of T cells as well as induction of autoantibody production by B cells. Given that MIF counter-regulates the effects of steroids, MIF antagonists may prove to be very effective, novel steroid-sparing agents for this life-threatening conundrum. |
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Authors:
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Mohammad Reza Namazi; Mohammad Kazem Fallahzadeh; Hassan Shaghelani; Eskandar Kamali-Sarvestani |
Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2009-10-01 |
Journal Detail:
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Title: International journal of dermatology Volume: 49 ISSN: 1365-4632 ISO Abbreviation: Int. J. Dermatol. Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-05-14 Completed Date: 2010-08-18 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0243704 Medline TA: Int J Dermatol Country: United States |
Other Details:
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Languages: eng Pagination: 146-8 Citation Subset: IM |
Affiliation:
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Dermatology Department, Shiraz University of Medical Sciences, Shiraz, Iran. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Biological Markers / blood Biopsy, Needle Case-Control Studies Disease Progression Enzyme-Linked Immunosorbent Assay Female Humans Immunohistochemistry Macrophage Migration-Inhibitory Factors / analysis, blood* Male Middle Aged Pemphigus / blood*, diagnosis, physiopathology* Probability Sensitivity and Specificity Severity of Illness Index Statistics, Nonparametric Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Macrophage Migration-Inhibitory Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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