| Marked amelioration of alcohol-responsive posthypoxic myoclonus by gamma-hydroxybutyric acid (Xyrem). | |
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MedLine Citation:
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PMID: 15751049 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We conducted an open-label, dose-finding, blinded-rating trial of gamma-hydroxybutyric acid (Xyrem) in a single patient with severe alcohol-responsive posthypoxic myoclonus refractory to treatment with standard antimyoclonic agents. Xyrem was given in divided doses during the day and was well tolerated. Intensity of myoclonus was measured using the Unified Myoclonus Rating Scale, and blinded videotape review demonstrated complete resolution of myoclonus at rest and stimulus-sensitive myoclonus. Action myoclonus and functional performance also improved in ways that were practically meaningful, allowing her to feed herself, to accomplish daily hygiene tasks, and to walk with assistance. The possible mechanisms of action and potential uses of this agent in other alcohol-responsive movement disorders are discussed. |
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Authors:
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Steven J Frucht; Yvette Bordelon; William H Houghton |
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Publication Detail:
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Type: Case Reports; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Movement disorders : official journal of the Movement Disorder Society Volume: 20 ISSN: 0885-3185 ISO Abbreviation: Mov. Disord. Publication Date: 2005 Jun |
Date Detail:
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Created Date: 2005-06-06 Completed Date: 2005-07-29 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8610688 Medline TA: Mov Disord Country: United States |
Other Details:
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Languages: eng Pagination: 745-51 Citation Subset: IM |
Copyright Information:
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(c) 2005 Movement Disorder Society. |
Affiliation:
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Department of Neurology, Columbia University Medical Center, 710 West 168th Street, New York, NY 10032, USA. sf216@columbia.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Central Nervous System Depressants / administration & dosage* Dose-Response Relationship, Drug Ethanol / administration & dosage* Female Humans Hydroxybutyrates / therapeutic use* Myoclonus / drug therapy* Neurologic Examination Psychomotor Performance / drug effects Severity of Illness Index Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Central Nervous System Depressants; 0/Hydroxybutyrates; 591-81-1/4-hydroxybutyric acid; 64-17-5/Ethanol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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