| Marked alterations in retinoid homeostasis of Sprague-Dawley rats induced by a single i.p. dose of 10 micrograms/kg of 2,3,7,8-tetrachlorodibenzo-p-dioxin. | |
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MedLine Citation:
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PMID: 2799829 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Interference of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in retinoid homeostasis was investigated in Sprague-Dawley rats with a low (dietary induced) retinoid status, that were fed a [3H]retinol-containing diet (37 MBq, 10,000 IU/kg diet) for 21 days to facilitate determination of retinoid concentrations in various tissues. The rats were exposed to a single i.p. dose of 10 micrograms TCDD/kg body weight in corn oil, or to corn oil at day 7 of [3H]retinol supplementation. TCDD induced significant reductions in retinol and retinyl ester concentrations and [3H] retinol-derived radioactivity in the liver, the lung, the intestine and the adrenals to 3-5%, 40-45%, 37%, and 56% of control values, respectively, at 14 days after exposure. In contrast, the retinoid concentrations and the amount of [3H]retinol-derived radioactivity in the kidney and serum of TCDD-treated rats was increased to 440% and 140% of corn oil-treated controls, respectively, at the termination time of the experiment. Analysis of the amount of serum retinol binding protein (RBP) by gel-permeation chromatography revealed an 150% increase in the free fraction of retinol-RBP, i.e., uncoupled to transthyretin (TTR), in serum of TCDD-treated rats. In addition, urinary excretion of [3H]retinol-derived radioactivity was significantly enhanced (to 140% of controls) by TCDD. These data indicate that TCDD induces an increased mobilization of retinoids from hepatic and extrahepatic storage sites into serum accompanied by an enhanced elimination via the kidney into the urine of rats. |
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Authors:
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A Brouwer; H Håkansson; A Kukler; K J Van den Berg; U G Ahlborg |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Toxicology Volume: 58 ISSN: 0300-483X ISO Abbreviation: Toxicology Publication Date: 1989 Oct |
Date Detail:
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Created Date: 1989-11-09 Completed Date: 1989-11-09 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0361055 Medline TA: Toxicology Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 267-83 Citation Subset: IM |
Affiliation:
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Department of Toxicology, Agricultural University Wageningen, The Netherlands. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenal Glands
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drug effects,
metabolism Animals Dioxins / toxicity* Female Homeostasis / drug effects* Intestines / drug effects, metabolism Liver / drug effects, metabolism Lung / drug effects, metabolism Prealbumin / metabolism Rats Rats, Inbred Strains Retinoids / metabolism* Retinol-Binding Proteins / metabolism Tetrachlorodibenzodioxin / toxicity* Vitamin A / administration & dosage, metabolism |
| Chemical | |
Reg. No./Substance:
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0/Dioxins; 0/Prealbumin; 0/Retinoids; 0/Retinol-Binding Proteins; 11103-57-4/Vitamin A; 1746-01-6/Tetrachlorodibenzodioxin |
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